FGF Receptor 3 (C51F2) Rabbit mAb 4574S from Cell Signaling Technology

Product Specs
ItemFGF Receptor 3 (C51F2) Rabbit mAb
CompanyCell Signaling Technology
Price $399.00 Inquire
Catalog Number4574S
Quantity100 µl
ApplicationsW, IP, IHC-P, IF-IC
ReactivityH
TargetFGFR3
HostRabbit
NCBI Gene AliasesACH, CD333, CEK2, HSFGFR3EX, JTK4
ClonalityMonoclonal
NCBI Full Gene Namefibroblast growth factor receptor 3
Research AreaRTK
IsotypeIgG
CloneC51F2
Molecular Weight165, 145 and 125

Questions and Answers

What applications has the FGF Receptor 3 antibody been used for in scientific research?

The FGF Receptor 3 (C51F2) Rabbit mAb has been shown to work in various applications including Western Blotting, Immunocytochemistry, Immunofluorescence, Immunohistochemistry, and Immunoprecipitation.

Is this antibody specific to human FGF Receptor 3, and how has it been validated in studies?

Yes, this antibody specifically detects endogenous levels of FGF Receptor 3 protein in humans and does not cross-react with other related family members. It has been cited in multiple studies, including those investigating its role in cancer and spermatogenesis, indicating its specificity and reliability in research contexts.

Can this antibody be used in studies related to cancer, and if so, how?

The FGF Receptor 3 antibody has been utilized in cancer research, such as in studies examining its role in hepatocellular carcinoma, where overexpression of FGFR3 correlates with more severe clinical features. It has also been implicated in the regulation of tumor progression and response to therapies in various cancer models.

What is the significance of using this antibody in studies of spermatogenesis?

The FGF Receptor 3 antibody has been employed in research to explore alterations in the spermatogonial stem cell compartment, particularly in patients with impaired spermatogenesis. This highlights its utility in understanding the regulatory mechanisms governing germ cell function and potential targets for addressing male infertility.

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Website: http://www.cellsignal.com/

Website: Technical Support

(1) Exploring the crosstalk between the FGF/FGFR pathway and tumor microenvironment in clear cell renal cell carcinomaPLoS OneFebruary 10, 2026Takafumi Narisawa, Sei Naito, Yoshihide Mitsuda, Rintaro Ohe, Hidenori Sato, Chizuru Kobayashi, Yuki Miyano, Hiromi Ito, Mitsuru Futakuchi, Norihiko Tsuchiyaused antibodies of CD163 (10D6, Leica Biosystems), FGFR1 (M17D10, Novus), FGFR2 (D4L2V, CST), FGFR3 (4574S, CST), FGFR4 (HPA027369, Sigma-Aldrich) to evaluate the number of macrophage and that of stromal tissue

(2) SREBP2-RAB11A-ZDHHC20 axis orchestrates FGFR3 palmitoylation and membrane retention to drive bladder cancer progressionCell Oncol (Dordr)January 26, 2026Wen-wen Zhang, Hao-ran Qu, Xuan-shuang Du, Su-juan Sun, Pin-ru Chen, Zi-han Deng, Qin Pan, Feng-ling Luo, Hong-yan Wu, Chao Song, et al.pellet were collected, protein-quantified, and analyzed by SDS-PAGE with antibodies to FGFR3 (CST #4574), Caveolin-1 (BD 610406), and Transferrin-R (Invitrogen 13-6800). Cholesterol depletion/re-loading

(3) Involvement of the FGF8 and Fibroblast Growth Factor Receptor signaling pathway in the maintenance and progression of fusion-positive rhabdomyosarcomaMolecular Cancer TherapeuticsDecember 15, 2025Salah Boudjadi, Hana Kim, Bishwanath Chatterjee, Pawan Kumar Raut, Thanh Hung. Nguyen, Puspa Raj Pandey, Reyaz ur ur Rasool, Wenyue Sun, Frederic G. BarrCell Signaling Technology Cat# 23328) (RRID:AB_2798862), FGFR3 (1:1000, Cell Signaling Technology Cat# 4574) (RRID:AB_2246903), FGFR4 (1:1000, Cell Signaling Technology Cat# 8562) (RRID:AB_10891199), FGF8 (1:1000,

(4) CDK2 inhibition enhances CDK4/6 inhibitor antitumor activity in comprehensive breast cancer PDX model screenNPJ Breast CancerDecember 3, 2025Nealia C. House, Maxine M. Chen, Sima Khazaei, Victoria Brown, Philip Ramsden, David H. Peng, Sydney Moore, Liang Yuan, Rentian Wu, Fangyang Wang, et al.FGFR1 1:1000 (CST 9740; RRID:AB_11178519), FGFR2 1:1000 (CST 23328; RRID:AB_2798862), FGFR3 1:1000 (CST 4574; RRID:AB_2246903), Aurora A/AIK 1:1000 (CST 4718; RRID:AB_2061482), Actin (R) 1:2000 (CST 8457; RRID:AB_10950489),

(5) PI3Kα Inhibitor and Degrader Inavolisib Can Co-opt FGFR2 to Enhance Responses in Patients with PIK3CA -Mutated Solid Tumors and in Preclinical ModelsClinical Cancer ResearchNovember 20, 2025Dejan Juric, Kyung Song, Radia M. Johnson, Melissa K. Accordino, Philippe L. Bedard, Andrés Cervantes, Valentina Gambardella, Erika Hamilton, Antoine Italiano, Kevin Kalinsky, et al.FGFR1 (cat. No. 9740, RRID: AB_11178519), FGFR2 (cat. No. 11835, RRID: AB_2797742), FGFR3 (cat. No. 4574, RRID: AB_2246903), FGFR4 (cat. No. 8562, RRID: AB_10891199), pFGFR Y653/654 (cat. No. 3476, RRID: AB_331369),

(6) Claudin-1 Contributes to Gastrointestinal Stromal Tumors (GIST) Resistance to Imatinib Mesylate (IM) via Regulation of FGFR-SignalingInternational Journal of Molecular SciencesAugust 22, 2025Sergei Boichuk, Firyuza Bikinieva, Pavel Dunaev, Aigul Galembikova, Ekaterina Mikheeva, Elena Valeeva, Shinjit Mani, Natalia Khromova, Pavel Kopnin, Leyla Shigapova, et al.(#5741T, lot:8), Beta-catenin (#8480T, lot:9), FGFR1 (#9740S, lot:4), FGFR2 (#23328S, lot:3), FGFR3 (#4574S, lot:2) (Cell Signaling, Danvers, MA, USA), KIT (#A4502, lot:11164713, Dako, Carpinteria, CA, USA),

(7) Prognostic related signature predicts the benefits of immunotherapy for kidney renal clear cell carcinomaDiscov OncolJune 19, 2025Feng Xiong, Bowen Wang, Haoxun Zhang, Guoling Zhang, Boju Tao, Yiwen Liu, Chunyang Wangantibodies overnight at 4 °C. The following antibodies were used: C1orf54 (Cell Signaling Technology #4574S), P2RX7 (Cell Signaling Technology #5786S), and SCN1B (Cell Signaling Technology #4903S). Cell proliferation

(8) Inflammatory Mediators Suppress FGFR2 Expression in Human Keratinocytes to Promote InflammationMolecular and Cellular BiologyNovember 1, 2024Luca Ferrarese, Michael Koch, Artemis Baumann, Liliana Bento-Lopes, Daria Wüst, Ivan Berest, Manfred Kopf, Sabine WernerFinland",1:1000 Rabbit anti-FGFR2 (D4L2V),"#23328, Cell Signaling Technology",1:1000 Rabbit anti-FGFR3 (C51F2),"#4574, Cell Signaling Technology",1:1000 Mouse anti-EGFR,"#sc-373746, Santa Cruz, Santa Cruz, CA",1:100 Rabbit

(9) Asparagine614 Determines the Transport and Function of the Murine Anti-Aging Protein KlothoCellsOctober 21, 2024Zahra Fanaei-Kahrani, Christoph KaetherAF1819" FGF Receptor 3 (C51F2),"rabbit, monoclonal",1:1000 in I-block,"Cell signaling technology, 4574" ERGIC-53 (B-9),"mouse, monoclonal",1:1000 in I-block,"Santa Cruz Biotechnology, Dallas, TX, USA, sc-271517" BiP

(10) FGFR2-triggered autophagy and activation of Nrf-2 reduce breast cancer cell response to anti-ER drugsCellular & Molecular Biology LettersMay 14, 2024Monika Gorska-Arcisz, Marta Popeda, Marcin Braun, Dominika Piasecka, Joanna I. Nowak, Kamila Kitowska, Grzegorz Stasilojc, Marcin Okroj, Hanna M. Romanska, Rafal Sadejanti-AMPKα (#5832), anti-phospho-AMPKα Thr172 (#2535), anti-FGFR1 (#9740), anti-FGFR2 (#23328), anti-FGFR3 (#4574), anti-FGFR4 (#8562), anti-Lamin B1 (#13435), anti-LC3B (#2775), anti-mTOR (#2983), anti-phospho-mTOR

(11) FGFR inhibition augments anti-PD-1 efficacy in murine FGFR3-mutant bladder cancer by abrogating immunosuppressionThe Journal of clinical investigationJanuary 16, 2024Okato A, Utsumi T, Ranieri M, Zheng X, Zhou M, Pereira LD, Chen T, Kita Y, Wu D, Hyun H, et al.antibodies against the following proteins: FGFR3 (C545F2) (rabbit mAb [1:1000]; Cell Signaling Technology, 4574), phospho-FGFR (Tyr653/654) (rabbit pAb [1:1000]; Cell Signaling Technology, 3471), Akt (pabbit pAb

(12) Preclinical characterization of CPL304110 as a potent and selective inhibitor of fibroblast growth factor receptors 1, 2, and 3 for gastric, bladder, and squamous cell lung cancerFrontiers in OncologyJanuary 12, 2024Delfina Popiel, Aleksandra Stańczak, Monika Skupińska, Agata Mikołajczyk, Paulina Stańczak, Filip Mituła, Joanna Hucz-Kalitowska, Kinga Jastrzębska, Damian Smuga, Jakub Dominowski, et al.using the following primary antibodies: anti-FGFR1 (D8E4, #9740), FGFR2 (D4H9; #11835), FGFR3 (C51F2, #4574S), anti-ERK (p44/42 MAPK (Erk1/2), #9102), and anti-pERK (p44/42 MAPK, #4370). The secondary antibody

(13) Transcriptional Heterogeneity Overcomes Super-Enhancer Disrupting Drug Combinations in Multiple MyelomaBlood Cancer DiscoveryJanuary 8, 2024Seth J. Welsh, Benjamin G. Barwick, Erin W. Meermeier, Daniel L. Riggs, Chang-Xin Shi, Yuan Xiao Zhu, Meaghen E. Sharik, Megan T. Du, Leslie D Abrego Abrego Rocha, Victoria M. Garbitt, et al.1:1,000), Cyclin D1 (A-12, Santa Cruz, sc-8396, used at 1:1,000), FGFR3 (C51F2, Cell Signaling Technology, #4574, used at 1:1,000), cMAF (M-153, Santa Cruz, sc7866, used at 1:1,000), b-Actin (AC-15, Abcam, ab6276,

(14) A novel FGFR1 inhibitor CYY292 suppresses tumor progression, invasion, and metastasis of glioblastoma by inhibiting the Akt/GSK3β/snail signaling axisGenes & diseasesJanuary 1, 2024Bi Y, Zheng R, Hu J, Shi R, Shi J, Wang Y, Wang P, Jiang W, Kim G, Liu Z, et al.(Cell Signaling, #9740, 1:1000), anti-FGFR2 (Cell Signaling, #23328, 1:1000), anti-FGFR3 (Cell Signaling, #4574, 1:1000), anti-phosphorylated FGFR2 (Cell Signaling, #3476, 1:1000), anti-glial fibrillary acidic protein

(15) Cell-based screen identifies porphyrins as FGFR3 activity inhibitors with therapeutic potential for achondroplasia and cancerJCI insightNovember 22, 2023Lin YW, Kao HJ, Chen WT, Kao CF, Wu JY, Chen YT, Lee YC.immunoblotting using RrGFP (Santa Cruz Biotechnology, sc-9996) and FGFR3 (Cell Signaling Technology, 4574) antibodies. For experiments not requiring immunoprecipitation, lysates were used for immunoblotting

(16) Single-cell signaling analysis reveals that Major Vault Protein facilitates RasG12C inhibitor resistancebioRxiv : the preprint server for biologyOctober 4, 2023Zhang JZ, Ong SE, Baker D, Maly DJ.anti-pan VDAC,Alomone Labs,AVC-001 Rb anti-Shp2,CST,3397S Ms anti-EGFR,Abcam,ab30 Rb anti-FGFR3,CST,4574S Gt anti-Biotin,Vector Labs,SP-3000-1 Rb anti-Biotin,Abcam,ab53494 Ms anti-Biotin,Abcam,ab201341 Rb

(17) FGF18 alleviates hepatic ischemia-reperfusion injury via the USP16-mediated KEAP1/Nrf2 signaling pathway in male miceNature communicationsSeptember 30, 2023Tong G, Chen Y, Chen X, Fan J, Zhu K, Hu Z, Li S, Zhu J, Feng J, Wu Z, et al.(Santa cruz, sc-393471, 1:1000), FGFR1 (CST, 9740S, 1:1000), FGFR2 (CST, 23328S, 1:1000), FGFR3 (CST, 4574S, 1:1000), FGFR4 (CST, 8562S, 1:1000), BCL-2 (Huabio, ET1702-53, 1:1000), BAX (CST 2772S, 1:1000), c-Cas-3

(18) 18F-labeled FGFR1 peptide: a new PET probe for subtype FGFR1 receptor imagingFrontiers in OncologyApril 27, 2023Yang Chen, Jingya Han, Yan Zhao, Xinming Zhao, Mengmeng Zhao, Jingmian Zhang, Jianfang Wangwere purchased from Cell Signaling Technology, Inc. (CST, USA) with catalog numbers 9740S, 23328S, 4574S and 8562S. The FGFR1-4 primary antibodies were diluted to 1:1000, and GAPDH was diluted to 1:10000 with

(19) OTUB1 promotes osteoblastic bone formation through stabilizing FGFR2Signal transduction and targeted therapyApril 7, 2023Zhu Q, Fu Y, Cui CP, Ding Y, Deng Z, Ning C, Hu F, Qiu C, Yu B, Zhou X, et al.antibody (GTX83953) was purchased from GeneTex. Anti-FGFR1 (9740), anti-FGFR2 (23328), anti-FGFR3 (4574), anti-AKT (4691), anti-p-Ser473-AKT (4060), anti-p-Ser308-AKT (13038), anti-ERK1/2 (4695), and anti-p-Thr202/Tyr204-ERK1/2

(20) Receptor clustering by a precise set of extracellular galectins initiates FGFR signalingCellular and molecular life sciences : CMLSApril 3, 2023Zukowska D, Gedaj A, Porebska N, Pozniak M, Krzyscik M, Czyrek A, Krowarsch D, Zakrzewska M, Otlewski J, Opalinski L.methods Antibodies and reagents The primary antibodies directed against FGFR1 (#9740), FGFR2 (#11835), FGFR3 (#4574), phospho-FGFR1 (pFGFR1; #3476), ERK1/2 (#9102), and phospho-ERK1/2 (pERK1/2; #9101) were from Cell Signaling

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FGF Receptor 3 (C51F2) Rabbit mAb

FGF Receptor 3 (C51F2) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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FGF Receptor 3 (C51F2) Rabbit mAb from Cell Signaling Technology

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