Anti-CD1A antibodies are used in the immunodetection of the protein CD1a molecule. In humans, the canonical protein has a reported length of 327 amino acid residues and a mass of 37.1 kDa. Its subcellular localization is in the cell membrane. It is noted to be expressed on cortical thymocytes, epidermal Langerhans cells, dendritic cells, on certain T-cell leukemias, and in various other tissues. CD1A is reported to be an antigen-presenting protein that binds self and non-self lipid and glycolipid antigens and presents them to T-cell receptors on natural killer T-cells. Post-translational modifications have been described, including glycosylation.
The CD1A marker can be used to identify Langerhans Cells, Rearranging Double Negative Thymocytes, and Double-Positive ?ß Thymocytes.* Synonyms for this target antigen include FCB6, HTA1, R4, T6, T-cell surface glycoprotein CD1a, and CD1. CD1A gene orthologs have been reported in the mouse, rat and chimpanzee species. Over 420 citations in the literature describe the use of CD1a antibodies in research. Flow Cytometry is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4