Anti-HTRA3 antibodies are used in the immunodetection of the protein HtrA serine peptidase 3. In humans, the canonical protein has a reported length of 453 amino acid residues and a mass of 48.6 kDa. It has been described to be a secreted protein. Up to 2 different isoforms have been reported for this protein. It is found to be widely expressed, with highest levels in both adult and fetal heart, ovary, uterus placenta, and bladder. A member of the Peptidase S1C protein family, HTRA3 is reported to be a serine protease that cleaves beta-casein/CSN2 as well as several extracellular matrix (ECM) proteoglycans such as decorin/DCN, biglycan/BGN and fibronectin/FN1. Synonyms for this target antigen include high-temperature requirement factor A3, pregnancy-related serine protease, probable serine protease HTRA3, and serine protease HTRA3. HTRA3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of HTRA3 antibodies have been mentioned in research publications and have associated citations. Immunohistochemistry is a widely used application for these antibodies. In addition, Western Blot is also a common application.