Anti-CMC1 antibodies are used in the immunodetection of the protein C-X9-C motif containing 1. In humans, the canonical protein has a reported length of 106 amino acid residues and a mass of 12.5 kDa. Its subcellular localization is in the mitochondria. It is notably widely expressed in many tissue types. A member of the CMC protein family, CMC1 is a known component of the MITRAC (mitochondrial translation regulation assembly intermediate of cytochrome c oxidase complex) complex, that regulates cytochrome c oxidase assembly.
The CMC1 marker can be used to identify Natural Killer Cells.* Synonyms for this target antigen include C-x(9)-C motif containing 1, COX assembly mitochondrial protein 1 homolog, CX9C mitochondrial protein required for full expression of COX 1, and COX assembly mitochondrial protein homolog. CMC1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Immunohistochemistry is the most common application for the CMC1 antibodies listed below. ELISA and Western Blot are also common applications.
*HuBMAP Human Reference Atlas v1.4