Anti-Neurofascin antibodies are used in the immunodetection of the protein encoded by the NFASC gene. In humans, the canonical protein has a reported length of 1347 amino acid residues and a mass of 150 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 13 different isoforms for this protein. A member of the L1/neurofascin/NgCAM protein family, it is known to be involved with axon guidance and brain development. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include NF, NRCAML, neurofascin homolog, and NEDCPMD.