Anti-ACSS1 antibodies are used in the immunodetection of the protein acyl-CoA synthetase short chain family member 1. In humans, the canonical protein has a reported length of 689 amino acid residues and a mass of 74.9 kDa. Its subcellular localization is in the mitochondria. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of a the ATP-dependent AMP-binding enzyme protein family, ACSS1 is known to catalyze the synthesis of acetyl-CoA from short-chain fatty acids. Post-translational modifications have been described, including acetylation. Synonyms for this target antigen include acetate--CoA ligase 2, propionate--CoA ligase, and acetyl-coenzyme A synthetase 2-like, mitochondrial.