Anti-polybromo 1 antibodies are used for the immunodetection of the protein encoded by the PBRM1 gene. In humans, the canonical protein has a reported length of 1689 amino acid residues and a mass of 192.9 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 9 different isoforms for this protein. It is widely expressed across many tissue types. It is known to be involved in transcriptional activation and repression of select genes by chromatin remodeling (alteration of DNA-nucleosome topology). The gene encoding this protein is implicated in Renal cell carcinoma. Other names for this target antigen include PB1, RCC, SMARCH1, protein polybromo-1, BRG1-associated factor 180, polybromo-1D, and BAF180. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 80 citations in the literature describe the use of polybromo 1 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.