Anti-PKD2 antibodies are used in the immunodetection of the protein polycystin 2, transient receptor potential cation channel. In humans, the canonical protein has a reported length of 968 amino acid residues and a mass of 109.7 kDa. Its subcellular localization is in the cell projections, ER, Golgi, and cell membrane. Up to 5 different isoforms have been reported for this protein. It is notably expressed in fetal and adult kidney. A member of the Polycystin protein family, PKD2 is a known component of the heteromeric calcium-permeable ion channel formed by PKD1 and PKD2 that is activated by interaction between PKD1 and a Wnt family member, such as WNT3A and WNT9B. The PKD2 gene has been associated with the disease, Polycystic kidney disease 2 with or without polycystic liver disease. Synonyms for this target antigen include PC2, PKD4, Pc-2, TRPP2, polycystin-2, and APKD2. PKD2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.