Anti-PION antibodies enable researchers to detect and measure the PION antigen in biological samples. This target is a reported synonym of the GSAP gene, which encodes gamma-secretase activating protein. This protein is a reported regulator of gamma-secretase activity, which specifically activates the production of amyloid-beta protein (amyloid-beta protein 40 and amyloid-beta protein 42), without affecting the cleavage of other gamma-secretase targets such has Notch. The human version of PION has a canonical amino acid length of 854 residues and a protein mass of 97.8 kilodaltons, although 4 isoforms have been identified. It is reported to be localized in the Golgi of cells. PION is a member of the GSAP protein family. Indicated applications for PION antibodies listed below include ELISA, Western Blot, Immunocytochemistry, Immunofluorescence, and Immunohistochemistry.