Anti-HR antibodies are used in the immunodetection of the protein HR lysine demethylase and nuclear receptor corepressor. In humans, the canonical protein has a reported length of 1189 amino acid residues and a mass of 127.5 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. HR is reported to be a histone demethylase that specifically demethylates both mono- and dimethylated 'Lys-9' of histone H3. The HR gene has been associated with the disease, Alopecia universalis congenita. Synonyms for this target antigen include [histone H3]-dimethyl-L-lysine(9) demethylase hairless, hair growth associated, hairless homolog, protein hairless, and lysine-specific demethylase hairless. HR gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Some HR antibodies may have been used in research and have associated citations. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.