Anti-AMBRA1 antibodies are used in the immunodetection of the protein autophagy and beclin 1 regulator 1. In humans, the canonical protein has a reported length of 1298 amino acid residues and a mass of 142.5 kDa. Its subcellular localization is in the nucleus, cytoplasmic vesicles, mitochondria, ER, and cytoplasm. Alternative splicing is reported to yield 6 different isoforms for this protein. A member of the WD repeat AMBRA1 protein family, it is known to be involved with autophagy pathways and the cell cycle. Post-translational modifications have been described, including ubiquitination, protein cleavage and phosphorylation. Synonyms for this target antigen include DDB1 and CUL4 associated factor 3, WD repeat domain 94, activating molecule in beclin-1-regulated autophagy, autophagy/beclin-1 regulator 1, and activating molecule in BECN1-regulated autophagy protein 1.