Anti-SOCS3 antibodies are used in the immunodetection of the protein suppressor of cytokine signaling 3. In humans, the canonical protein has a reported length of 225 amino acid residues and a mass of 24.8 kDa. It is reported to be widely expressed with high expression in the heart, placenta, skeletal muscle, peripheral blood leukocytes, fetal and adult lung, and fetal liver and kidney. SOCS3 is known to be involved with intracellular signal transduction and the regulation of apoptosis. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include CIS3, Cish3, SSI-3, SSI3, STAT-induced STAT inhibitor 3, cytokine-inducible SH2 protein 3, and ATOD4. SOCS3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 120 citations in the literature describe the use of SOCS3 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.