Anti-MAGEL2 antibodies are used in the immunodetection of the protein MAGE family member L2. In humans, the canonical protein has a reported length of 1249 amino acid residues and a mass of 132.8 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be expressed in the placenta, fetal and adult brain. MAGEL2 is suspected to be enhances ubiquitin ligase activity of RING-type zinc finger-containing E3 ubiquitin-protein ligases, possibly through recruitment and/or stabilization of the Ubl-conjugating enzyme (E2) at the E3:substrate complex. The MAGEL2 gene has been associated with the disease, Schaaf-Yang syndrome. Synonyms for this target antigen include PWLS, SHFYNG, nM15, MAGE-like protein 2, melanoma antigen family L2, necdin-like protein 1, protein nM15, and NDNL1. MAGEL2 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Immunohistochemistry is the most common application for the MAGEL2 antibodies listed below. ELISA, Western Blot, and Immunofluorescence are also common applications.