Anti-MMP13 antibodies are used in the immunodetection of the protein matrix metallopeptidase 13. In humans, the canonical protein has a reported length of 471 amino acid residues and a mass of 53.8 kDa. Its subcellular localization is in the extracellular matrix and is secreted. It is notably expressed in the cartilage. A member of the Peptidase M10A protein family, MMP13 is reported to play a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Post-translational modifications have been described, including N-glycosylation, protein cleavage and phosphorylation. The MMP13 gene has been associated with the disease, Spondyloepimetaphyseal dysplasia. Synonyms for this target antigen include MANDP1, MDST, collagenase 3, matrix metalloproteinase 13 (collagenase 3), and CLG3. MMP13 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species.