Anti-MMP13 antibody [N3C1], Internal GTX100665 from GeneTex

Product Specs
ItemAnti-MMP13 antibody [N3C1], Internal
CompanyGeneTex
Price $169.00Supplier Page
Catalog NumberGTX100665
Conjugate/TagUnconjugated
Quantity25 µl
FormatPBS, 20% Glycerol, 0.025% ProClin 300
ApplicationsWB, ICC/IF, IHC-P, IHC-Fr
ReactivityHuman, Mouse, Rat
ClonalityPolyclonal
HostRabbit
ImmunogenCarrier-protein conjugated synthetic peptide encompassing a sequence within the center region of human MMP13. The exact sequence is proprietary
Concentration0.56mg/ml
IsotypeIgG
Antibody TypePrimary Antibodies
NCBI Full Gene Namematrix metallopeptidase 13
NCBI Gene AliasesMMP-13, matrix metallopeptidase 13, CLG3, MANDP1, MDST, MMP-13, CLG3, MDST, MANDP1
PurityPurified by antigen-affinity chromatography
TargetMMP13
Research AreaCancer, Cell Biology
Gene NameMMP13
Molecular Weight54

Questions and Answers

Can this antibody be used for immunohistochemistry in cartilage studies?

Yes, the Anti-MMP13 antibody [N3C1], Internal has been utilized in immunohistochemistry applications, as demonstrated in studies examining osteoarthritis where it was used to detect matrix metalloproteinase-13 expression in cartilage samples ().

What species does this antibody recognize, and is it effective for multiple models?

The Anti-MMP13 antibody recognizes human, mouse, and rat proteins, making it suitable for use in various experimental models involving these species ().

Has this antibody been cited in research related to osteoarthritis?

Yes, the Anti-MMP13 antibody has been cited in multiple studies focusing on osteoarthritis, including its role in the degradation of the extracellular matrix and the regulation of chondrocyte behavior in both in vitro and in vivo models (; ).

What applications has this antibody been validated for in scientific research?

The Anti-MMP13 antibody has been validated for use in Western blotting, immunocytochemistry, immunofluorescence, and various forms of immunohistochemistry, including paraffin-embedded and frozen sections ().

GeneTex

GeneTex, Inc. 2456 Alton Parkway

Irvine, California 92606

United States

Phone: 1-877-GeneTex (436-3839) or 949-553-1900
Fax: 949-309-2888

Company Profile

Website: http://www.genetex.com

(1) Cross-Linked Versus Linear Hyaluronic Acid for Cartilage Repair in Rat Post-Traumatic OsteoarthritisJ Orthop ResApril 27, 2026Tien-Ching Lee, Chih-Ming Kao, Yi-Wun Lin, Yi-Shan Lin, Yan-Hsiung Wang, Hsuan-Fu Chen, Yin-Chih Fuhyaluronic acid receptor and mesenchymal stem cell marker.4.Matrix metalloproteinase‐13 (MMP‐13) (GeneTex, GTX100665; 1:200 dilution): cartilage degradation enzyme.5.Tumor necrosis factor‐alpha (TNF‐α) (Bioworld, BS1857;

(2) Enhancing exosomes efficacy with engineered nanozymes for a multi-targeted combination strategy in osteoarthritis treatmentMater Today BioApril 12, 2026Chenyue Xu, Zhengyi Ni, Qi Wang, Handi Li, Lie Wu, Yuhang Shi, Xiaobo Chen, Ziyi Li, Huijun Kang, Yanxin Liu, et al.were calculated according to previous study [69]. IHC stanning of Col II (GTX100829, GeneTex), MMP13 (GTX100665, GeneTex), GPX4 (30388-1-AP, Proteintech), and ALOX12 (A14703, ABclonal) were also conducted. 4.23

(3) Targeting EFEMP1 enhances chondrogenesis and inhibits hypertrophic differentiation in a spontaneous osteoarthritis mouse modelJ Mol Med (Berl)March 18, 2026Yuhan Chang, Pei-Heng Jiang, Yung-Heng Hsu, Yu-Chih Lin, Chih-Chien Hu, Yi-Zhen Li, Steve Wen-Neng Ueng, Mei-Feng Chen(1:100, NBP1-77040; NOVUS, USA), SOX9 (1:50, sc-166505; Santa Cruz Biotechnology, USA), MMP-13 (1:100, GTX100665; GeneTex, USA), aggrecan fragments (1:100, AF1220; R&D Systems, USA), COL2A1 (1:100, ab34712; Abcam,

(4) Artemisia argyi-enhanced Mesenchymal Stem Cell Exosomes Alleviates Inflammation in C28/I2 Chondrocytes by inhibiting NF-κBInt J Med SciFebruary 18, 2026Shih-Wen Kao, Yu-Ting Hsu, Wei-Wen Kuo, Tai-Lung Huang, Kuan-Ho Lin, Chia-Hua Kuo, Dennis Jine-Yuan Hsieh, Tsung-Jung Ho, Shinn-Zong Lin, Chih-Yang HuangCell signaling), IκB-α (sc-1643, Santa Cruz), COL2A1 (GB11021; Servicebio, Wuhan, Hubei, China), MMP-13 (GTX100665; GeneTex, Irvine, CA, USA), Nanog (#4903, Cell Signaling), KLF4 (#4038, Cell signaling), CXCR4 (60042-1-Ig;

(5) Osteoclast‐Derived SLIT3 Mediates Osteoarthritis Pain and Degenerative ChangesAdvanced ScienceNovember 19, 2025Weiwei Zhu, Wenpin Qin, Jialu Gao, Yihan Guo, Xiaoxiao Han, Zhangyu Ma, Xiaokang Zhang, Jie He, Jing Liu, Bo Gao, et al.used were Matrix metalloproteinase (MMP9, 1:500, GTX100458, GeneTex, Irvine, CA, USA), MMP13 (1:50, GTX100665, GeneTex), Type‐II collagen (Col2, 1:50, ab34712, Abcam), SLIT3 (1:50, DF9909, Affinity Biosciences),

(6) Chronic intermittent hypobaric hypoxia alleviates early-stage posttraumatic osteoarthritis via NF-κB/Nrf2 pathway in miceJournal of orthopaedic surgery and researchDecember 26, 2024Ren G, Geng L, Ren D, Hou H, Yao S, Shi Z, Wang P.mechanism changes. Materials and methods Chemicals and reagents Primary antibodies against MMP13 (GTX100665) were purchased from GeneTex, Inc. (Alton Pkwy Irvine, USA). Primary antibodies against cartilage oligomeric

(7) The role of EDIL3 in maintaining cartilage extracellular matrix and inhibiting osteoarthritis developmentBone & joint researchDecember 12, 2023Chen MF, Hu CC, Hsu YH, Lin YC, Chen KL, Ueng SWN, Chang Y.SOX9 (1:50, sc-166505; Santa Cruz Biotechnology); and 5) matrix metalloproteinase (MMP)-13 (1:100, GTX100665; GeneTex, USA). For Safranin O staining, sections were incubated in Weigert’s iron haematoxylin (HT1079),

(8) Characterization and Advancement of an Evaluation Method for the Treatment of Spontaneous Osteoarthritis in STR/ort Mice: GRGDS Peptides as a Potential Treatment for OsteoarthritisBiomedicinesApril 6, 2023Chen MF, Hu CC, Hsu YH, Chiu YT, Chen KL, Ueng SWN, Chang Y.(3) Sox9 (1:50, sc-166505, Santa Cruz Biotechnology, Inc., Delaware, CA, USA), and (4) MMP13 (1:100, GTX100665, GeneTex, Irvine, CA, USA). For Safranin O staining, sections were incubated in Weigert’s iron hematoxylin

(9) FOXO3-Activated circFGFBP1 Inhibits Extracellular Matrix Degradation and Nucleus Pulposus Cell Death via miR-9-5p/BMP2 Axis in Intervertebral Disc Degeneration In Vivo and In VitroPharmaceuticals (Basel, Switzerland)March 22, 2023Tan Y, Wang X, Zhang Y, Dai Z, Li J, Dong C, Yao X, Lu C, Chen F.determined using the microscope (Olympus, Tokyo, Japan). Anti-BMP2 (GTX64355, 1:50) and anti-MMP-13 (GTX100665, 1:200) were purchased from GeneTex. We used a TUNEL staining kit to detect apoptosis in NP tissues.

(10) Therapeutic effect of induced pluripotent stem cell -derived extracellular vesicles in an in vitro and in vivo osteoarthritis modelJournal of orthopaedic translationJanuary 1, 2023Hsueh YH, Buddhakosai W, Le PN, Tu YY, Huang HC, Lu HE, Chen WL, Tu YK.GeneTex, Inc. at 1:1000, CD9 (GTX66709), CD81 (GTX31381), TSG101 (GTX70255), p21 (GTX629543), MMP13 (GTX100665), ADAMTS5 (GTX100332), iNOS (GTX60599), and TNF-α (GTX110520), at 1:1500, IL-6 (GTX110527), and at 1:3000,

(11) Celastrol ameliorates osteoarthritis via regulating TLR2/NF-κB signaling pathwayFrontiers in pharmacologyJanuary 1, 2022Yang G, Wang K, Song H, Zhu R, Ding S, Yang H, Sun J, Wen X, Sun L.at room temperature, incubated with antibodies against matrix metalloproteinase 13 (MMP13, 1:1000, GTX100665, GeneTex, CA, USA), CollagenII (1:1000, ab34712, Abcam, Cambridge, UK), cyclooxygenase-2 (COX2, 1:1000,

(12) Cutaneous Regeneration Mechanism of β-Sheet Silk Fibroin in a Rat Burn Wound Healing ModelPolymersOctober 14, 2021Chou KC, Chen CT, Cherng JH, Li MC, Wen CC, Hu SI, Wang YW.rabbit anti-MMP-13, mouse anti-α-smooth muscle actin (SMA) (GTX26308, GTX102997, GTX00674, GTX100704, GTX100665, GTX629702, respectively; 1:1000; GeneTex, Irvine, CA, USA). After removing the immersing solution,

(13) PP2A in LepR+ mesenchymal stem cells contributes to embryonic and postnatal endochondral ossification through Runx2 dephosphorylationCommunications biologyJune 2, 2021Yen YT, Chien M, Wu PY, Hung SC.1:500), anti-Osterix (Bioss bs-1110, 1:300), anti-collagen X (Abcam ab58632, 1:100), anti-MMP13 (Genetex GTX100665, 1:500) and anti-GAPDH (Genetex GTX-100118, 1:5000) were used. Immunoprecipitation was performed by

(14) Knockdown of hsa_circ_0134111 alleviates the symptom of osteoarthritis via sponging microRNA-224-5pCell cycle (Georgetown, Tex.)June 1, 2021Zhang L, Sui C, Zhang Y, Wang G, Yin Z.

(15) Melatonin impedes prostate cancer metastasis by suppressing MMP-13 expressionJournal of cellular physiologyMay 1, 2021Wang SW, Tai HC, Tang CH, Lin LW, Lin TH, Chang AC, Chen PC, Chen YH, Wang PC, Lai YW, et al.

(16) Parathyroid hormone (1-34) ameliorates cartilage degeneration and subchondral bone deterioration in collagenase-induced osteoarthritis model in miceBone & joint researchOctober 1, 2020Shao LT, Gou Y, Fang JK, Hu YP, Lian QQ, Zhang YY, Wang YD, Tian FM, Zhang L.

(17) Progesterone receptor membrane component 1 is involved in oral cancer cell metastasisJournal of cellular and molecular medicineSeptember 1, 2020Huang HY, Chou HC, Law CH, Chang WT, Wen TN, Liao EC, Lin MW, Lin LH, Wei YS, Tsai YT, et al.

(18) Duration of postoperative immobilization affects MMP activity at the healing graft-bone interface: Evaluation in a mouse ACL reconstruction modelJournal of orthopaedic research : official publication of the Orthopaedic Research SocietyFebruary 1, 2019Nakagawa Y, Lebaschi AH, Wada S, Green SJE, Wang D, Album ZM, Carballo CB, Deng XH, Rodeo SA.trypsin for 15min at 37°C. Sections were then incubated with the primary antibody (MMP13 antibody, GTX100665, purified rabbit polyclonal IgG, GeneTex, Irvine, CA). A secondary antibody (ImmPRESS Anti-Rabbit Ig

(19) AAV serotype 8-mediated liver specific GNMT expression delays progression of hepatocellular carcinoma and prevents carbon tetrachloride-induced liver damageScientific reportsSeptember 14, 2018Fang CC, Wu CF, Liao YJ, Huang SF, Chen M, Chen YA.

(20) Extrahepatic angiogenesis hinders recovery of portal hypertension and collaterals in rats with cirrhosis resolutionClinical science (London, England : 1979)March 30, 2018Hsu SJ, Tsai MH, Chang CC, Hsieh YH, Huang HC, Lee FY, Chuang CL, Hou MC, Lee SD.

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Anti-MMP13 antibody [N3C1], Internal

Anti-MMP13 antibody [N3C1], Internal

Anti-MMP13 antibody [N3C1], Internal

Anti-MMP13 antibody [N3C1], Internal

Anti-MMP13 antibody [N3C1], Internal from GeneTex

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Anti-MMP13 antibody [N3C1], Internal from GeneTex

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