Anti-SCEL antibodies are used in the immunodetection of the protein sciellin. In humans, the canonical protein has a reported length of 688 amino acid residues and a mass of 77.6 kDa. Its subcellular localization is in the cytoplasm. Up to 3 different isoforms have been reported for this protein. It is reported to be highly expressed in esophagus. SCEL is believed to function in the assembly or regulation of proteins in the cornified envelope. The SCEL marker can be used to identify Alveolar Type I Cells.* SCEL gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Western Blot is the most common application for the scel antibodies listed below. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4