Anti-SMC3 antibodies are used in the immunodetection of the protein structural maintenance of chromosomes 3. In humans, the canonical protein has a reported length of 1217 amino acid residues and a mass of 141.5 kDa. Its subcellular localization is in the nucleus. It is notably widely expressed in many tissue types. A member of the SMC protein family, SMC3 is reported to be a central component of cohesin, a complex required for chromosome cohesion during the cell cycle. Post-translational modifications have been described, including ubiquitination, acetylation and phosphorylation. Synonyms for this target antigen include BMH, CDLS3, CSPG6, HCAP, SMC3L1, structural maintenance of chromosomes protein 3, SMC protein 3, and BAM. SMC3 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 110 citations in the literature describe the use of SMC3 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.