Anti-AGR2 antibodies are used in the immunodetection of the protein anterior gradient 2, protein disulphide isomerase family member. In humans, the canonical protein has a reported length of 175 amino acid residues and a mass of 20 kDa. Its subcellular localization is in the ER and is secreted. It is noted to be expressed strongly in trachea, lung, stomach, colon, prostate and small intestine. A member of the AGR protein family, AGR2 is known to be required for MUC2 post-transcriptional synthesis and secretion.
The AGR2 marker can be used to identify Bronchus Submucosal Gland Mucus Secreting Cells, Lobar Bronchus Epithelium Goblet Cells, Tracheobronchial Goblet Cells, and Trachea Gland Mucus Secreting Cells.* Synonyms for this target antigen include AG2, GOB-4, HAG-2, HEL-S-116, HPC8, PDIA17, RIFTD, and AG-2. AGR2 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of AGR2 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4