Fig 2: Expression of the PAUF-associated proteins AGR2, BRD7, and POM121 in patients with cervical cancer. (A) Representative examples of positive and negative expression of the AGR2, BRD7, and POM121 proteins. The scale bar represents 50 µm. (B) Correlations between expression of PAUF and PAUF-related proteins in cervical cancer tissues. AGR2 protein expression was positively correlated with POM121 expression (r = 0.33, p < 0.001).

Fig 3: Hierarchical clustering analysis for immunohistochemical expression of PAUF-associated proteins in cervical cancer patients. (A) Three cluster groups were identified in the present study. Category 1 (n = 118, blue arrow) consists of relatively high AGR2 and POM121 expression. Category 2 (n = 194, red arrow) consists of relatively low AGR2 and PAUF expression. Category 3 (n = 24, green arrow) consists of relatively high PAUF and low POM121 expression. (B) Kaplan–Meier plot for overall survival according to group by hierarchical clustering. A tendency toward decreased overall survival was observed in Category 3 than in the other groups (log-rank test, p = 0.053).