Anti-RNASEL antibodies are used in the immunodetection of the protein ribonuclease L. In humans, the canonical protein has a reported length of 741 amino acid residues and a mass of 83.5 kDa. Its subcellular localization is in the mitochondria and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is reported to be highly expressed in spleen and thymus followed by prostate, testis, uterus, small intestine, colon and peripheral blood leukocytes. A member of the Protein kinase protein superfamily, RNASEL is a reported endoribonuclease that functions in the interferon (IFN) antiviral response. Synonyms for this target antigen include RNS4, 2-5A-dependent ribonuclease, 2',5'-oligoisoadenylate synthetase-dependent, 2-5A-dependent RNase, interferon-induced 2-5A-dependent RNase, and PRCA1. RNASEL gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. A number of RNASEL antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.