Anti-MTDH antibodies are used in the immunodetection of the protein metadherin. In humans, the canonical protein has a reported length of 582 amino acid residues and a mass of 63.8 kDa. Its subcellular localization is in the nucleus, ER, and cytoplasm. It is notably widely expressed in many tissue types. MTDH is known to be involved with the regulation of apoptosis and the regulation of transcription. Synonyms for this target antigen include 3D3/LYRIC, astrocyte elevated gene 1, astrocyte elevated gene-1 protein, lysine-rich CEACAM1 co-isolated protein, metastasis adhesion protein, and protein LYRIC. MTDH gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 180 citations in the literature describe the use of MTDH antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.