Anti-ALDH2 antibodies are used in the immunodetection of the protein aldehyde dehydrogenase 2 family member. In humans, the canonical protein has a reported length of 517 amino acid residues and a mass of 56.4 kDa. Its subcellular localization is in the mitochondria. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the adrenal gland and kidney. A member of the Aldehyde dehydrogenase protein family, ALDH2 is known to be required for clearance of cellular formaldehyde, a cytotoxic and carcinogenic metabolite that induces DNA damage. The ALDH2 marker can be used to identify CD8?- Thymic Conventional Dendritic Cells.* Synonyms for this target antigen include ALDHI, ALDM, aldehyde dehydrogenase, mitochondrial, ALDH class 2, acetaldehyde dehydrogenase 2, and ALDH-E2. ALDH2 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4