Anti-DIS3L2 antibodies are used in the immunodetection of the protein DIS3 like 3'-5' exoribonuclease 2. In humans, the canonical protein has a reported length of 885 amino acid residues and a mass of 99.3 kDa. Its subcellular localization is in the cytoplasm. Up to 5 different isoforms have been reported for this protein. It is notably widely expressed in many tissue types. A member of the RNR ribonuclease protein family, DIS3L2 is a reported 3'-5'-exoribonuclease that specifically recognizes RNAs polyuridylated at their 3' end and mediates their degradation. The DIS3L2 gene has been associated with the disease, Perlman syndrome. Synonyms for this target antigen include DIS3 mitotic control homolog-like 2, family with sequence similarity 6, member A, and DIS3-like exonuclease 2. DIS3L2 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Some DIS3L2 antibodies may have been used in research and have associated citations. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.