Anti-SLC9A3 antibodies are used in the immunodetection of the protein solute carrier family 9 member A3. In humans, the canonical protein has a reported length of 834 amino acid residues and a mass of 92.9 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the appendix and colon. A member of the Monovalent cation:proton antiporter 1 (CPA1) transporter (TC 2.A.36) protein family, SLC9A3 is known to be involved in pH regulation to eliminate acids generated by active metabolism or to counter adverse environmental conditions.
The SLC9A3 marker can be used to identify Type 2 Descending Thin Limb Cells.* Synonyms for this target antigen include NHE-3, NHE3, sodium/hydrogen exchanger 3, Na(+)/H(+) exchanger 3, and DIAR8. SLC9A3 gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 110 citations in the literature describe the use of SLC9A3 antibodies in research. Western Blot is a widely used application for these antibodies. Immunocytochemistry, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4