Anti-PAWR antibodies are used in the immunodetection of the protein pro-apoptotic WT1 regulator. In humans, the canonical protein has a reported length of 340 amino acid residues and a mass of 36.6 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is widely expressed across many tissue types. PAWR is known to be involved with the apoptotic pathway and the regulation of gene expression. Post-translational modifications have been described, including phosphorylation.
The PAWR marker can be used to identify Gray Matter MGE Interneurons.* Synonyms for this target antigen include Par-4, PRKC apoptosis WT1 regulator protein, PRKC, apoptosis, WT1, regulator, prostate apoptosis response protein 4, and PAR4. PAWR gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of PAWR antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4