HTRA2 is a symbol for the gene, HtrA serine peptidase 2, in humans. Other names include: Serine protease HTRA2, mitochondrial; High temperature requirement protein A2; HtrA2; Omi stress-regulated endoprotease; Serine protease 25; Serine proteinase OMI; Serine protease HTRA2, mitochondrial ; OMI; PARK13; PRSS25. The encoded protein is an enzyme with an amino acid length of 458 and a mass of 48.8 kDa. Other isoforms may exist. HTRA2 is a member of the Peptidase S1C family. This gene shares homology with other species, including: Mouse, Rat.