HTRA2/Omi Antibody AF1458 from R&D Systems, a Bio-Techne Brand

Product Specs
ItemHTRA2/Omi Antibody
CompanyR&D Systems, a Bio-Techne Brand
Price $419.00Supplier Page View Company Product Page
Catalog NumberAF1458
NCBI Gene AliasesPRSS25, OMI, MGCA8, PARK13
ApplicationsCo-Immunoprecipitation,Immunohistochemistry,Western Blot,Immunohistochemistry-Frozen,Simple Western,Immunocytochemistry,ELISA Capture
Quantity100 ug (also 25 ug)
IsotypeIgG
TargetHTRA2/Omi
HostRabbit
ReactivityHamster,Human,Mouse,Rat
Conjugate/TagUnconjugated
FormatLyophilized from a 0.2 µm filtered solution in PBS with Trehalose. *Small pack size (SP) is supplied either lyophilized or as a 0.2 µm filtered solution in PBS
NCBI Full Gene NameHtrA serine peptidase 2
ClonalityPolyclonal
ImmunogenE. coli-derived recombinant human HTRA2/Omi, Ala134-Glu458, Accession # O43464
ConcentrationLYOPH
PurityAntigen Affinity-purified
Antibody TypePrimary Antibodies
StorageUse a manual defrost freezer and avoid repeated freeze-thaw cycles. 12 months from date of receipt, -20 to -70 °C as supplied. 1 month, 2 to 8 °C under sterile conditions after reconstitution. 6 months, -20 to -70 °C under sterile conditions after reconstitution

Specifications/Features

Available conjugates: Available conjugates: Unconjugated

Specificity: Detects human, mouse, and rat full length and mitochondria-processed HTRA2/Omi.

Sizes Available: 100 ug (also 25 ug)

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R&D Systems, a Bio-Techne Brand

614 McKinley Place N.E.

Minneapolis, Minnesota 55413

United States

Phone: 1 (800) 343-7475
1 (612) 379-2956

Fax: 1 (612) 656-4400

Company Profile

Website: http://www.rndsystems.com

(1) Stress-induced OMA1-mediated cleavage of AIFM1 suppresses cell growth by controlling mitochondrial OXPHOS activityThe EMBO JournalMarch 24, 2026Mitsuhiro Nishigori, Serina Hirata, Hidetaka Kosako, Takeshi Ichinohe, Hendrik Nolte, Jan Riemer, Thomas Langer, Takumi Koshibarabbit polyclonal",Cell Signaling Technology,Cat# 4870 "Anti-HTRA2/Omi, rabbit polyclonal",R&D Systems,AF1458 "Anti-MAVS, rabbit polyclonal","Koshiba et al, 2011",N/A "Anti-MFN2 (XX-1), mouse monoclonal",Santa Cruz Biotechnology

(2) Diastolic dysfunction in Alzheimer's disease model mice is associated with Aβ-amyloid aggregate formation and mitochondrial dysfunctionScientific reportsJuly 19, 2024Aishwarya R, Abdullah CS, Remex NS, Bhuiyan MAN, Lu XH, Dhanesha N, Stokes KY, Orr AW, Kevil CG, Bhuiyan MS.Mfn2 (1:1000; 9482; Cell Signaling), SAM50 (1:300; sc-100493; Santa Cruz Biotechnology), HtrA2 (1:500; AF1458; R&D Systems), HSC70 (1:1000; ab2788; Abcam), ClpP (1:200; sc-271284; Santa Cruz Biotechnology), LonP1

(3) Protease-independent control of parthanatos by HtrA2/OmiCellular and molecular life sciences : CMLSAugust 18, 2023Weiß J, Heib M, Korn T, Hoyer J, Fuchslocher Chico J, Voigt S, Koudelka T, Tholey A, Adam D.specific for HtrA2/Omi (15775-1-AP, Proteintech, Rosemont, IL, USA), ab75982 (Abcam, Cambridge, UK), or AF1458 (R&D Systems, Minneapolis, MN, USA), LONP1 (ab103809, Abcam), PMPCA (ab140171, Abcam), PARP-1 (9542,

(4) Pleiotropic effects of mdivi-1 in altering mitochondrial dynamics, respiration, and autophagy in cardiomyocytesRedox biologySeptember 1, 2020Aishwarya R, Alam S, Abdullah CS, Morshed M, Nitu SS, Panchatcharam M, Miriyala S, Kevil CG, Bhuiyan MS.Sigma), ClpP (1:200, sc-271284, Santacruz), Paraplegin (1:200, sc-514393, Santacruz), HTRA2 (1:500, AF1458, R&D Systems), Rab24 (1:200, sc-136049, Santacruz), and VCP (1:500, 2648, Cell Signalling). Membranes

(5) Cytosolic Trapping of a Mitochondrial Heat Shock Protein Is an Early Pathological Event in SynucleinopathiesCell reportsJuly 2, 2019Szegő ÉM, Dominguez-Meijide A, Gerhardt E, König A, Koss DJ, Li W, Pinho R, Fahlbusch C, Johnson M, Santos P, et al.

(6) Increased Active OMI/HTRA2 Serine Protease Displays a Positive Correlation with Cholinergic Alterations in the Alzheimer's Disease BrainMolecular neurobiologyJuly 1, 2019Darreh-Shori T, Rezaeianyazdi S, Lana E, Mitra S, Gellerbring A, Karami A, Bogdanovic N, Lithner CU, Winblad B, Behbahani H.with 50 μL/well of 0.25 μg/mL of capturing antibody (rabbit polyclonal anti-OMI/HTRA2 antibody, cat#AF1458; R&D Systems, UK) in coating buffer (100 mM carbonate buffer, pH 9.8, and containing 0.01% thimerosal

(7) Bcl-2 inhibitors enhance FGFR inhibitor-induced mitochondrial-dependent cell death in FGFR2-mutant endometrial cancerMolecular oncologyApril 1, 2019Packer LM, Stehbens SJ, Bonazzi VF, Gunter JH, Ju RJ, Ward M, Gartside MG, Byron SA, Pollock PM.Abcam; FGFR2 (sc‐122), FRS2 (sc‐8318) and Tom20 (sc‐11415) from Santa Cruz Biotechnology; and HTRA2/OMI (AF1458) from R&D Systems. 2.5 Flow cytometry measurement of cytochrome c release We followed the method described

(8) Subcellular origin of mitochondrial DNA deletions in human skeletal muscleAnnals of neurologyAugust 1, 2018Vincent AE, Rosa HS, Pabis K, Lawless C, Chen C, Grünewald A, Rygiel KA, Rocha MC, Reeve AK, Falkous G, et al.factor A, mitochondrial (TFAM; Abcam Ab119684), NEF2L2 (Abcam ab31163), ClpP (Sigma HPA010649), Htra2 (AF1458; R&D Systems, Minneapolis, MN), mtHsp70 (Thermo Fisher Scientific), Hsp60 (611562; BD Biosciences, Franklin

(9) The multi-subunit GID/CTLH E3 ubiquitin ligase promotes cell proliferation and targets the transcription factor Hbp1 for degradationeLifeJune 18, 2018Lampert F, Stafa D, Goga A, Soste MV, Gilberto S, Olieric N, Picotti P, Stoffel M, Peter M.

(10) PARL mediates Smac proteolytic maturation in mitochondria to promote apoptosisNature cell biologyApril 1, 2017Saita S, Nolte H, Fiedler KU, Kashkar H, Venne AS, Zahedi RP, Krüger M, Langer T.

(11) Protease Omi cleaving Hax-1 protein contributes to OGD/R-induced mitochondrial damage in neuroblastoma N2a cells and cerebral injury in MCAO miceActa pharmacologica SinicaSeptember 1, 2015Wu JY, Li M, Cao LJ, Sun ML, Chen D, Ren HG, Xia Q, Tao ZT, Qin ZH, Hu QS, et al.

(12) Protease Omi facilitates neurite outgrowth in mouse neuroblastoma N2a cells by cleaving transcription factor E2F1Acta pharmacologica SinicaAugust 1, 2015Ma Q, Hu QS, Xu RJ, Zhen XC, Wang GH.were used for immunoblot analysis: anti-α-Tubulin (CP06, Calbiochem, San Diego, CA, USA), anti-Omi (AF1458, R&D Systems, Minneapolis, MN, USA), anti-E2F1 (KH95, Santa Cruz Biotechnology, Santa Cruz, CA, USA),

(13) Heat shock inhibition of CDK5 increases NOXA levels through miR-23a repressionThe Journal of biological chemistryMay 1, 2015Morey TM, Roufayel R, Johnston DS, Fletcher AS, Mosser DD.

(14) Influenza A virus protein PB1-F2 translocates into mitochondria via Tom40 channels and impairs innate immunityNature communicationsAugust 20, 2014Yoshizumi T, Ichinohe T, Sasaki O, Otera H, Kawabata S, Mihara K, Koshiba T.

(15) The ubiquitin-conjugating enzymes UBE2N, UBE2L3 and UBE2D2/3 are essential for Parkin-dependent mitophagyJournal of cell scienceAugust 1, 2014Geisler S, Vollmer S, Golombek S, Kahle PJ.

(16) p53-mediated activation of the mitochondrial protease HtrA2/Omi prevents cell invasionThe Journal of cell biologyMarch 31, 2014Yamauchi S, Hou YY, Guo AK, Hirata H, Nakajima W, Yip AK, Yu CH, Harada I, Chiam KH, Sawada Y, et al.

(17) Neural-specific deletion of Htra2 causes cerebellar neurodegeneration and defective processing of mitochondrial OPA1PloS oneJanuary 1, 2014Patterson VL, Zullo AJ, Koenig C, Stoessel S, Jo H, Liu X, Han J, Choi M, DeWan AT, Thomas JL, et al.

(18) The role of PARL and HtrA2 in striatal neuronal injury after transient global cerebral ischemiaJournal of cerebral blood flow and metabolism : official journal of the International Society of Cerebral Blood Flow and MetabolismNovember 1, 2013Yoshioka H, Katsu M, Sakata H, Okami N, Wakai T, Kinouchi H, Chan PH.immunoblotted. Anti-PARL (1:500, ARP44851; Aviva Systems Biology, San Diego, CA, USA), anti-HtrA2 (1:2,000, AF1458; R&D Systems, Minneapolis, MN, USA), anti-cytochrome c (1:1,000, 556433; BD Biosciences, San Jose, CA,

(19) Parkinson's disease-associated mutations in DJ-1 modulate its dimerization in living cellsJournal of molecular medicine (Berlin, Germany)May 1, 2013Repici M, Straatman KR, Balduccio N, Enguita FJ, Outeiro TF, Giorgini F.(anti-DJ-1, sc-55572, Santa Cruz Biotechnology), 1:1,000 (anti GFP, ab6556 Abcam), 1:200 (anti-HtrA2, AF1458, R&D Systems), 1:100 (anti-Vimentin, 5741, Cell Signalling Technology), in blocking solution and incubated

(20) PINK1/Parkin-mediated mitophagy is dependent on VDAC1 and p62/SQSTM1Nature cell biologyFebruary 1, 2010Geisler S, Holmström KM, Skujat D, Fiesel FC, Rothfuss OC, Kahle PJ, Springer W.

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HTRA2/Omi Antibody

HTRA2/Omi Antibody

HTRA2/Omi Antibody

HTRA2/Omi Antibody

HTRA2/Omi Antibody

HTRA2/Omi Antibody from R&D Systems, a Bio-Techne Brand

Specifications/Features

R&D Systems, a Bio-Techne Brand

Citations (37)

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HTRA2/Omi Antibody from R&D Systems, a Bio-Techne Brand

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