Anti-PRNP antibodies are used in the immunodetection of the protein prion protein. In humans, the canonical protein has a reported length of 253 amino acid residues and a mass of 27.7 kDa. Its subcellular localization is in the Golgi and cell membrane. It is notably expressed in the skin, colon, cerebral cortex, cerebellum, and caudate. A member of the Prion protein family, PRNP is known to be involved with the cell cycle and the regulation of apoptosis. Post-translational modifications have been described, including N-glycosylation. The PRNP gene has been associated with the disease, Creutzfeldt-Jakob disease. Synonyms for this target antigen include AltPrP, CD230, CJD, GSS, KURU, PRIP, PrP, and ASCR. PRNP gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species. Over 130 citations in the literature describe the use of PRNP antibodies in research. ELISA, Western Blot, and Immunohistochemistry are common applications for these antibodies.