Anti-Prion protein PrP antibody [EP1802Y] ab52604 from Abcam

Product Specs
ItemAnti-Prion protein PrP antibody [EP1802Y]
CompanyAbcam
Price Supplier Page View Company Product Page
Catalog Numberab52604
Antibody TypePrimary
ClonalityMonoclonal
IsotypeIgG
CloneEP1802Y
HostRabbit
ApplicationsFlow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Flow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot, Flow Cytometry, Immunohistochemistry (Formalin/PFA-fixed paraffin-embedded sections), Western blot
Quantity10 UL, 40 UL, 100 UL
Conjugate/TagUnconjugated
Research AreaNeuroscience
Gene NamePRNP
ReactivityHuman, Mouse, Rat
TargetPrion protein PrP

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Abcam

Discovery Drive

Cambridge Biomedical Campus

Cambridge CB2 0AX

United Kingdom

Phone: +44 (0) 1223 696000 (option 1)
+44 (0) 1223 696000 (option 2)
+44 (0) 1223 771600

Company Profile

Website: http://www.abcam.com

(1) FMRP, FXR1 protein and Dlg4 mRNA, which are associated with fragile X syndrome, are involved in the ubiquitin-proteasome systemScientific reportsFebruary 2, 2023Shimizu H, Hohjoh H.dilution ratios in parentheses: Anti-DLG4 (ab2723, 1/2000), anti-FMRP (ab17722, 1/2000) and anti-PRNP (ab52604, 1/5000) were purchased from Abcam (Cambridge, UK). Anti-FXR1 (13,194–1-AP, 1/5000), anti-PSMA7 (15,219–1-AP,

(2) ER entry pathway and glycosylation of GPI-anchored proteins are determined by N-terminal signal sequence and C-terminal GPI-attachment sequenceThe Journal of biological chemistryOctober 1, 2022Hirata T, Yang J, Tomida S, Tokoro Y, Kinoshita T, Fujita M, Kizuka Y.(clone 4D5) (catalog no.: 14-9230-82) from eBioscience; rabbit anti-Prion (clone EP1802Y) (catalog no.: ab52604) from Abcam; mouse anti-human CD59 (clone 5H8), mouse anti-ITM1 (STT3A) (clone A-2) (catalog no.: sc-390227)

(3) PrP concentration in the central nervous system: regional variability, genotypic effects, and pharmacodynamic impactJCI InsightMarch 22, 2022Meredith A. Mortberg, Hien T. Zhao, Andrew G. Reidenbach, Juliana E. Gentile, Eric Kuhn, Jill Oâ€™Moore, Patrick M. Dooley, Theresa R. Connors, Curt Mazur, Shona W. Allen, et al.Fisher Scientific 439454) were coated overnight at 4°C with 2.0 μg/mL EP1802Y capture antibody (Abcam ab52604) in PBS, sealed with clear adhesive MicroAmp Film (Life 4306311) and then washed 3 times with 300 μL

(4) Loss of the N-acetylgalactosamine side chain of the GPI-anchor impairs bone formation and brain functions and accelerates the prion disease pathologyThe Journal of biological chemistryMarch 1, 2022Hirata T, Kobayashi A, Furuse T, Yamada I, Tamura M, Tomita H, Tokoro Y, Ninomiya A, Fujihara Y, Ikawa M, et al.anti-GFP mAb (clone EPR14104-89), anti-NeuN mAb (clone 1B7), and goat anti-Iba1, from Abcam (ab220360, ab52604, ab95701, ab183735, ab104224, and ab5076); rabbit anti-GFP, from MBL (598); rabbit anti-MAP2, from Santa Cruz

(5) Hippocampal proteomic changes of susceptibility and resilience to depression or anxiety in a rat model of chronic mild stressTranslational psychiatryOctober 17, 2019Tang M, Huang H, Li S, Zhou M, Liu Z, Huang R, Liao W, Xie P, Zhou J.ab214486, Abcam), Por (1:10,000; ab180597, Abcam), Prdx6 (1:1,000; ab133348, Abcam), Prnp (1:5,000; ab52604, Abcam), and Tpp2 (1:1,000; ab180177, Abcam). Anti-mouse or anti-rabbit horseradish peroxidase-conjugated

(6) Changes in Membrane Protein Clustering in Peripheral Lymphocytes in an Animal Model of Depression Parallel Those Observed in Naïve Depression Patients: Implications for the Development of Novel Biomarkers of DepressionFrontiers in PharmacologyOctober 15, 2018Raquel Romay-Tallon, Erin Kulhawy, Kyle J. Brymer, Josh Allen, Tania Rivera-Baltanas, Jose M. Olivares, Lisa E. Kalynchuk, Hector J. Caruncho(1:150, Cat# RA24288, Neuromics); anti-β2AR (1:150, Cat# SAB1306036, Sigma); anti-PrPc (1:200, Cat# ab52604, Abcam); anti-NR2B (1:200, Cat# SAB4300711, Sigma); antiDAT (1:250, Cat#D6944, Sigma); anti-Pannexin1

(7) A novel vector for transgenesis in the rat CNSActa Neuropathologica CommunicationsDecember 1, 2017T. Peter Lopez, Kurt Giles, Brittany N. Dugger, Abby Oehler, Carlo Condello, Zuzana Krejciova, Julian A. Castaneda, George A. Carlson, Stanley B. Prusinerincubated in a primary antibody cocktail containing a 1:250 dilution of a rabbit PrP antibody (Abcam, ab52604) and 1:500 dilution of chicken GFAP (Abcam, ab4674) overnight at room temperature. The following day,

(8) Role of the central lysine cluster and scrapie templating in the transmissibility of synthetic prion protein aggregatesPLoS PathogensSeptember 14, 2017Bradley R. Groveman, Gregory J. Raymond, Katrina J. Campbell, Brent Race, Lynne D. Raymond, Andrew G. Hughson, Christina D. Orrú, Allison Kraus, Katie Phillips, Byron Caughey

(9) Systematic protein-protein interaction mapping for clinically relevant human GPCRsMolecular systems biologyMarch 15, 2017Sokolina K, Kittanakom S, Snider J, Kotlyar M, Maurice P, Gandía J, Benleulmi-Chaachoua A, Tadagaki K, Oishi A, Wong V, et al.(sc‐9110), OXTR (sc‐33209). Abcam: ADRB2 (ab36956), HNRPK (ab52600), F2RL (ab124227), TTYH1 (ab57582), PRNP (ab52604), MGLL (ab24701), ATP2A2 (ab2861), FA2H (ab54615), HSPA1B (ab79852). Cell Signaling: GABBR1 (3835).

(10) Luman contributes to brefeldin A-induced prion protein gene expression by interacting with the ERSE26 elementScientific reportsFebruary 13, 2017Déry MA, LeBlanc AC.Vikram Misra, University of Saskatchewan, Saskatoon, SK), anti-PrP (1:10,000, 3F4, PrP109-112 or 1:500 ab52604, PrP214-230, Abcam, Toronto, ON), anti-BiP (C50B12, 1:5,000, Cell Signaling, Beverly MA or H-129 (1:2,500,

(11) Human prion protein-induced autophagy flux governs neuron cell damage in primary neuron cellsOncotargetMay 24, 2016Ji-Hong Moon, Ju-Hee Lee, Uddin Md MD. Nazim, You-Jin Lee, Jae-Won Seol, Seong-Kug Eo, John-hwa Lee, Sang-Youel Park(#5114, Cell Signaling Technology), anti-ATG5 (#2630, Cell Signaling Technology), anti-prion protein (ab52604, Abcam, Cambridge, MA, USA) and anti-β-actin (A5441, Sigma Aldrich). Images were examined using a Fusion

(12) Conformation-dependent epitopes recognized by prion protein antibodies probed using mutational scanning and deep sequencingJournal of molecular biologyJanuary 30, 2015Doolan KM, Colby DW.comparison to a FLAG standard (Sigma P7457). MAb EP1802Y was purchased from a commercial source (Abcam ab52604). Generation of mutant PrP library The wild-type mouse PrP gene encoding the mature form of the protein

(13) Genetic prion disease: no role for the immune system in disease pathogenesis?Human molecular geneticsAugust 1, 2014Yael Friedman-Levi, Orli Binyamin, Kati Frid, Haim Ovadia, Ruth Gabizon

(14) OCIAD2 activates γ-secretase to enhance amyloid β production by interacting with nicastrinCellular and molecular life sciences : CMLSJuly 1, 2014Han J, Jung S, Jang J, Kam TI, Choi H, Kim BJ, Nah J, Jo DG, Nakagawa T, Nishimura M, et al.hybridoma), anti-V5 (Sigma-Aldrich, S2540), anti-LC3 (Novus Biologicals, NB600-1384), anti-PRNP (Abcam, ab52604), anti-FLOT1 (BD Biosciences, 610821), anti-FACL4 (kindly gifted from Dr. S.M. Prescott, University

(15) Live imaging of prions reveals nascent PrPSc in cell-surface, raft-associated amyloid strings and websThe Journal of cell biologyFebruary 3, 2014Rouvinski A, Karniely S, Kounin M, Moussa S, Goldberg MD, Warburg G, Lyakhovetsky R, Papy-Garcia D, Kutzsche J, Korth C, et al.

(16) Targeted knock-down of cellular prion protein expression in myelinating Schwann cells does not alter mouse prion pathogenesisThe Journal of general virologyJune 1, 2013Sophie Halliez, Nathalie Chesnais, Giovanna Mallucci, Marthe Vilotte, Christelle Langevin, Emilie Jaumain, Hubert Laude, Jean-Luc Vilotte, Vincent Béringue

(17) PrP(C) homodimerization stimulates the production of PrPC cleaved fragments PrPN1 and PrPC1The Journal of neuroscience : the official journal of the Society for NeuroscienceSeptember 19, 2012Maxime Béland, Julie Motard, Alice Barbarin, Xavier Roucou

(18) Highly neurotoxic monomeric a-helical prion proteinProceedings of the National Academy of Sciences of the United States of AmericaFebruary 21, 2012Minghai Zhou, Gregory Ottenberg, Gian Franco Sferrazza, Corinne Ida Lasmézas

(19) Early mechanisms of pathobiology are revealed by transcriptional temporal dynamics in hippocampal CA1 neurons of prion infected micePLoS pathogensJanuary 1, 2012Anna Majer, Sarah J Medina, Yulian Niu, Bernard Abrenica, Kathy J Manguiat, Kathy L Frost, Clark S Philipson, Debra L Sorensen, Stephanie A Booth

(20) Prion protein expression and the M129V polymorphism of the PRNP gene in patients with colorectal cancerMolecular carcinogenesisJuly 1, 2010Anna G Antonacopoulou, Maria Palli, Stella Marousi, Fotinos-Ioannis Dimitrakopoulos, Urania Kyriakopoulou, Athanasios C Tsamandas, Chrisoula D Scopa, Athanasios G Papavassiliou, Haralabos P Kalofonos

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Anti-Prion protein PrP antibody [EP1802Y] from Abcam

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Anti-Prion protein PrP antibody [EP1802Y] from Abcam

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