Anti-TDP1 antibodies are used in the immunodetection of the protein tyrosyl-DNA phosphodiesterase 1. In humans, the canonical protein has a reported length of 608 amino acid residues and a mass of 68.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Up to 2 different isoforms have been reported for this protein. It is ubiquitously expressed across many tissue types. A member of the Tyrosyl-DNA phosphodiesterase protein family, TDP1 is known to be involved with DNA repair. Post-translational modifications have been described, including phosphorylation. The TDP1 gene has been associated with the disease, Spinocerebellar ataxia. Synonyms for this target antigen include tyr-DNA phosphodiesterase 1. TDP1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of TDP1 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. In addition, ELISA is also a common application.