Fig 1: Effect of 13-chlorine-3,15-dioxy-gibberellic acid methyl ester on the expression of proteins involved in the chemosensitivity of tumor cell lines. (A) Protein expression levels were normalized to β-actin and quantified using ImageJ v1.49 software, and (B) data are presented as the mean ± standard deviation of three independent experiments. *P<0.05, **P<0.01 and ***P<0.001 vs. 0 weeks (control); #P<0.05 vs. 4 weeks; φP<0.05 vs. 8 weeks. Top1, topoisomerase I; Tdp1, tyrosyl DNA phosphodiesterase 1; Chk1, checkpoint kinase 1; Bcl-2, B-cell lymphoma-2.