Anti-folliculin antibodies are used for the immunodetection of the protein encoded by the FLCN gene. In humans, the canonical protein has a reported length of 579 amino acid residues and a mass of 64.5 kDa. Its subcellular localization is in the nucleus, lysosomes and cytoplasm. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be expressed in most tissues tested, including skin, lung, kidney, heart, testis and stomach. A member of the Folliculin protein family, it is known to be a multi-functional protein, involved in both the cellular response to amino acid availability and in the regulation of glycolysis. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include BHD skin lesion fibrofolliculoma protein and birt-Hogg-Dube syndrome protein. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. A number of folliculin antibodies have been mentioned in research publications and have associated citations. ELISA, Western Blot, Immunofluorescence, and Immunohistochemistry are common applications for these antibodies.