FLCN (D14G9) Rabbit mAb 3697S from Cell Signaling Technology

Product Specs
ItemFLCN (D14G9) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number3697S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetFLCN
HostRabbit
NCBI Gene AliasesBHD, DENND8B, FLCL
ClonalityMonoclonal
NCBI Full Gene Namefolliculin
Research AreaPI3K / Akt Signaling
IsotypeIgG
CloneD14G9
Molecular Weight70

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Targeting the FNIP2-SERCA2b axis improves metabolic and mitochondrial defects in Ataxia TelangiectasiaCell Death DisMarch 2, 2026Maria Vinciguerra, Catiana El Kharef, Christopher Bruhn, Lucia Falbo, Chiara Milanese, Matteo Audano, Galina V. Beznoussenko, Alexander A. Mironov, Domenico Delia, Marco Foiani, et al.Vinculin (PA5-29688, Invitrogen); FNIP2 (HPA042779, Atlas antibody); FNIP1 (Ab134969, Abcam); FLCN (3697 s, Cell Signaling); SERCA2b antibody (clone 2A7-A1; #MA3-919, ThermoFisher Scientific), GAPDH (G8795,

(2) SFPQ-TFE3 reciprocally regulates mTORC1 and induces lineage plasticity in a mouse model of renal tumorigenesisNat CommunOctober 3, 2025Kaushal Asrani, Adrianna Amaral, Juhyung Woo, Sanaz Nourmohammadi Abadchi, Thiago Vidotto, Eddie Imada, Alyza Skaist, Kewen Feng, Hans B. Liu, Mithila Kasbe, et al.and reagents Primary antibodies 4E-BP1 (#9644 CST; 1:2000), CTSK (#ab19027 Abcam; 1:1000), FLCN (#3697 CST; 1:1000), GAPDH (#5174 CST; 1:1000), GATA3(#5852 CST; 1:500), GPNMB (#38313 CST; 1:1000), GPNMB

(3) Reactive oxygen species control protein degradation at the mitochondrial import gateMolecular CellDecember 5, 2024Rachael McMinimy, Andrew G. Manford, Christine L. Gee, Srividya Chandrasekhar, Gergey Alzaem Mousa, Joelle Chuang, Lilian Phu, Karen Y. Shih, Christopher M. Rose, John Kuriyan, et al.anti-FEM1B,Proteintech,Cat# 11030-1-AP; RRID:AB_2102637 Rabbit monoclonal anti-FLCN (D14G9),Cell Signaling Technology,Cat#3697; RRID:AB_2231646 Rabbit monoclonal anti-GAPDH (D16H11 XP),Cell Signaling Technology,Cat#5174; RRID:AB_10622025 Mouse

(4) Schizophrenia-associated NRXN1 deletions induce developmental-timing- and cell-type-specific vulnerabilities in human brain organoidsNature communicationsJune 24, 2023Sebastian R, Jin K, Pavon N, Bansal R, Potter A, Song Y, Babu J, Gabriel R, Sun Y, Aronow B, et al.follows: mouse anti-Ki67 (1:250, BD Biosciences BDB550609), rabbit anti-SOX2 (1:500 Cell Signaling 3697S), rabbit anti-HOPX (1:500, Proteintech 11419-1-H), rat anti-CTIP2 (1:2000, Abcam ab18465), rabbit anti-TBR2

(5) Role of FLCN Phosphorylation in Insulin-Mediated mTORC1 Activation and TumorigenesisAdvanced science (Weinheim, Baden-Wurttemberg, Germany)June 1, 2023Wang G, Chen L, Lei X, Qin S, Geng H, Zheng Y, Xia C, Yao J, Meng T, Deng L.(2217S), pS473‐AKT (9271), AKT (9272), mTOR (2983S), Rictor (9476), Raptor (2280), SIN1 (D7G1A), FLCN (3697), TFEB (37785), WDR59 (53385), RagA (4357), RagC (9480), RagD (4470), AKT‐substrate (10001), Ki‐67 (12202S),

(6) PRDM10 directs FLCN expression in a novel disorder overlapping with Birt-Hogg-Dubé syndrome and familial lipomatosisHuman molecular geneticsMarch 20, 2023van de Beek I, Glykofridis IE, Oosterwijk JC, van den Akker PC, Diercks GFH, Bolling MC, Waisfisz Q, Mensenkamp AR, Balk JA, Zwart R, et al.to individual datasheets: PRDM10 Bethyl (A303-204A, Bethyl laboratories, TX, USA), FLCN (D14G9, CST 3697S, Cell Signaling Technologies, MA, USA), GPNMB (AF2550-SP, R&D systems, MN, USA), PTEN (sc-7974, Santa Cruz

(7) TFEB-mediated lysosomal exocytosis alleviates high-fat diet-induced lipotoxicity in the kidneyJCI insightFebruary 22, 2023Nakamura J, Yamamoto T, Takabatake Y, Namba-Hamano T, Minami S, Takahashi A, Matsuda J, Sakai S, Yonishi H, Maeda S, et al.2983), ACTB (MilliporeSigma, A5316), HA (MilliporeSigma, 11867423001), FLCN (Cell Signaling Technology, 3697), GABARAP (MBL, PM037), LAMP1 (BD Biosciences, 553792 for mouse samples; BD Biosciences, 555798 for

(8) Structural basis for FLCN RagC GAP activation in MiT-TFE substrate-selective mTORC1 regulationScience advancesSeptember 16, 2022Jansen RM, Peruzzo R, Fromm SA, Yokom AL, Zoncu R, Hurley JH.study: phospho-T389 S6K1 (9234S), S6K1 (2708S), phospho-S65 4EBP (9451S), 4EBP (9644S and 9452S), FLCN (3697), TFE3 (14779), TFEB (37785), V5 (13202), FLAG (14793) (all from Cell Signaling Technology), and LAMP2

(9) A Rag GTPase dimer code defines the regulation of mTORC1 by amino acidsNature cell biologySeptember 1, 2022Gollwitzer P, Grützmacher N, Wilhelm S, Kümmel D, Demetriades C.DYKDDDDK (FLAG) tag (#2368), mTOR (#2983), RagA (#4357), RagB (#8150), RagC (#9480), RagD (#4470), FLCN (#3697) and CTSD (#2284) proteins were purchased from Cell Signaling Technology. Anti-Raptor (#20984-1-AP)

(10) Phosphoproteomic Analysis of FLCN Inactivation Highlights Differential Kinase Pathways and Regulatory TFEB PhosphoserinesMolecular & cellular proteomics : MCPSeptember 1, 2022Glykofridis IE, Henneman AA, Balk JA, Goeij-de Haas R, Westland D, Piersma SR, Knol JC, Pham TV, Boekhout M, Zwartkruis FJT, et al.https://github.com/Boekhout/imageJ_TFEB Antibodies For Western blot experiments the following antibodies were used: FLCN (D14G9, CST 3697S, 1:1000), RRAGD (CST 4470S, 1:1000), TFE3 (CST 14779, 1:1000), TFEB (CST 3778, D2O7D; 1:3000), GAPDH

(11) A specialized Hsp90 co-chaperone network regulates steroid hormone receptor response to ligandCell reportsJuly 12, 2022Backe SJ, Sager RA, Regan BR, Sit J, Major LA, Bratslavsky G, Woodford MR, Bourboulia D, Mollapour M.,Enzo Life Sciences,Cat# ADI-SPA-670; RRID:AB_10617386 Rabbit anti-FLCN (D14G9),Cell Signaling Technology,Cat# 3697; RRID:AB_2231646 Mouse anti-Src (L4A1),Cell Signaling Technology,Cat# 2110; RRID:AB_10691385 Mouse

(12) Tandem Mass Tagging (TMT) Reveals Tissue-Specific Proteome of L4 Larvae of Anisakis simplex s. s.: Enzymes of Energy and/or Carbohydrate Metabolism as Potential Drug Targets in AnisakiasisInternational Journal of Molecular SciencesApril 14, 2022Robert Stryiński, Jesús Mateos, Mónica Carrera, Jan Paweł Jastrzębski, Iwona Bogacka, Elżbieta Łopieńska-BiernatOGDH (1:1000; cat. no 26865; Cell Signaling Technology, Danvers, MA, USA) and FLCN (1:1000; cat. no 3697; Cell Signaling Technology, Danvers, MA, USA). After incubation, the membranes were washed 3 times for

(13) TSC2 regulates lysosome biogenesis via a non-canonical RAGC and TFEB-dependent mechanismNature CommunicationsDecember 1, 2021Nicola Alesi et al.14779), Cathepsin K (CTS K) (Abcam, ab19027), NPC1 (Abcam, ab134113), FLCN (Cell Signaling Technology, 3697), GFP (1:5000) (Abcam, ab13970), phosphorylated TFEB S211 (Cell Signaling Technology, 37681), phosphorylated

(14) The Lysosomal Rag-Ragulator Complex Licenses RIPK1 and Caspase-8-mediated Pyroptosis by YersiniaScience (New York, N.Y.)June 25, 2021Zheng Z, Deng W, Bai Y, Miao R, Mei S, Zhang Z, Pan Y, Wang Y, Min R, Deng F, et al.(#3493), Phospho-RIPK1 (#31122), RagC (#3360, #9480), Lamtor1 (#8975), Lamtor4 (#12284) and FLCN (#3697) were from Cell Signaling Technology. Monoclonal anti-FADD antibody (sc-166516) and monoclonal anti-KDEL

(15) Rag GTPases and phosphatidylinositol 3-phosphate mediate recruitment of the AP-5/SPG11/SPG15 complexThe Journal of cell biologyFebruary 1, 2021Hirst J, Hesketh GG, Gingras AC, Robinson MS.Cell Signaling Technology), rabbit anti-LAMTOR1 (8975; Cell Signaling Technology), rabbit anti-folliculin (anti-FLCN; 3697; Cell Signaling Technology), rabbit anti-NPRL2 (37344; Cell Signaling Technology), mouse anti-GFP for

(16) Loss of FLCN-FNIP1/2 induces a non-canonical interferon response in human renal tubular epithelial cellseLifeJanuary 18, 2021Glykofridis IE, Knol JC, Balk JA, Westland D, Pham TV, Piersma SR, Lougheed SM, Derakhshan S, Veen P, Rooimans MA, et al.antibodies were used according to individual datasheets: Vinculin (H-10, sc-25336), FLCN (D14G9, CST 3697S), Cas9 (epigentek A-9000–050), AQP1 (sc-25287), GPNMB (AF2550-SP), SQSTM1 (CST 88588), RRAGD (CST_ 4470S),

(17) FLCN regulates transferrin receptor 1 transport and iron homeostasisThe Journal of biological chemistryJanuary 1, 2021Wang X, Wu H, Zhao L, Liu Z, Qi M, Jin Y, Liu W.procedures Reagents Antibodies specific for the following proteins were used: FLCN (Cell Signaling Technology; #3697), TfR1 (Santa Cruz; #3B82A1), HA (Abcam; #9110), GFP (TransGen Biotech; #HT801), beta-actin (Sungene

(18) Mitochondrial respiratory chain deficiency inhibits lysosomal hydrolysisAutophagySeptember 1, 2019Fernandez-Mosquera L, Yambire KF, Couto R, Pereyra L, Pabis K, Ponsford AH, Diogo CV, Stagi M, Milosevic I, Raimundo N.(Cell Signaling Technology, 2795), p-PRKAA1/AMPKα1 (T172) (Cell Signaling Technology, 2535), FLCN (Cell Signaling Technology, 3697), FNIP1 (Abcam, ab134969), TSC2 (Cell Signaling Technology, 4308), p-TSC2 (S1387) (Cell Signaling Technology,

(19) The Transcription Factors TFEB and TFE3 Link the FLCN-AMPK Signaling Axis to Innate Immune Response and Pathogen ResistanceCell reportsMarch 26, 2019El-Houjeiri L, Possik E, Vijayaraghavan T, Paquette M, Martina JA, Kazan JM, Ma EH, Jones R, Blanchette P, Puertollano R, et al.Sigma-Aldrich), LaminA (SC-71481; Santa Cruz Biotechnology), AMPKα (2532; Cell Signaling Technology), human FLCN 3697; Cell Signaling Technology), p-AMPKα (Thr172) (2531; Cell Signaling Technology), ACC (3676; Cell Signaling Technology

(20) The primary cilium protein folliculin is part of the autophagy signaling pathway to regulate epithelial cell size in response to fluid flowCell stressFebruary 25, 2019Zemirli N, Boukhalfa A, Dupont N, Botti J, Codogno P, Morel E.were used in immunoblotting: rabbit-anti LC3 (Sigma, Cat#L7543); rabbit-anti-FLCN (Cell signaling, Cat#3697); rabbit-anti-FNIP1 (Abcam, Cat#ab134969); rabbit-anti-AMPK (Cell signaling, Cat#2532S); rabbit-anti-p-AMPK

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FLCN (D14G9) Rabbit mAb

FLCN (D14G9) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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FLCN (D14G9) Rabbit mAb from Cell Signaling Technology

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