Anti-UHRF1 antibodies are used in the immunodetection of the protein ubiquitin like with PHD and ring finger domains 1. In humans, the canonical protein has a reported length of 793 amino acid residues and a mass of 89.8 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. It is reported to be expressed in thymus, bone marrow, testis, lung and heart. UHRF1 is reported to be a multidomain protein that acts as a key epigenetic regulator by bridging DNA methylation and chromatin modification. Post-translational modifications have been described, including ubiquitination and phosphorylation.
The UHRF1 marker can be used to identify Double-Positive ?ß Thymocytes.* Synonyms for this target antigen include Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95, E3 ubiquitin-protein ligase UHRF1, and ICBP90. UHRF1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species. Over 90 citations in the literature describe the use of UHRF1 antibodies in research. Western Blot is a widely used application for these antibodies. Immunofluorescence and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4