UHRF1 (D6G8E) Rabbit mAb 12387S from Cell Signaling Technology

Product Specs
ItemUHRF1 (D6G8E) Rabbit mAb
CompanyCell Signaling Technology
Price $339.00 Inquire
Catalog Number12387S
Quantity100 µl
ApplicationsW, IP
ReactivityH, M, R
TargetUHRF1
HostRabbit
NCBI Full Gene Nameubiquitin like with PHD and ring finger domains 1
NCBI Gene AliasesICBP90, Np95, RNF106, TDRD22, hNP95, hUHRF1, huNp95
ClonalityMonoclonal
Research AreaChromatin Regulation / Nuclear Function
CloneD6G8E
Molecular Weight95

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Cell Signaling Technology

3 Trask Lane

Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) Deep-learning-based de novo discovery and design of therapeutics that reverse disease-associated transcriptional phenotypesCellMarch 17, 2026Jing Xing, Mingdian Tan, Dmitry Leshchiner, Mengying Sun, Mohamed Abdelgied, Li Huang, Shreya Paithankar, Katie Uhl, Rama Shankar, Erika Lisabeth, et al.then blocked using 5% nonfat milk for 1 h and incubated with primary antibodies against UHRF1 (cat# 12387S, Cell Signaling Technology, 1:1,000 dilution), GAPDH (cat# 60004–1-Ig, Proteintech, 1:20,000 dilution).

(2) Identification of unique biomarkers in colorectal cancer based on comprehensive analysis and machine learningFrontiers in OncologyJanuary 26, 2026Liwei Wang, Aigang Ren, Xiaolong Cui, Yuan Shen, Qingxing HuangAntibodies,Dilution,Manufacturer,Cat. no. UHRF1 (D6G8E) rabbit mAb,"1:1,000",CST,12387 Anti-SND1,1 μg/mL,Abcam,Ab65078 Anti-PTTG1IP,"1:1,000",Abcam,Ab128040 BRCA1 (E5S9G) rabbit mAb,"1:1,000",CST,50799 Recombinant

(3) Myc-associated zinc finger protein drives colorectal cancer metastasis through activating ubiquitin like with ring finger protein oneWorld Journal of Gastrointestinal OncologyNovember 15, 2025Hui-Qin Mao, Fang-Cao Yu, Dan-Qiong Hu, Li-Jing ZhangMA, United States). MAZ (1:1000; 21068-1-AP) was from Proteintech (Wuhan, China), and UHRF1 (1:1000; #12387), E-cadherin (1:1000; #3195), N-cadherin (1:1000; #13116), vimentin (1:1000; #5741), Snail (1:1000;

(4) The SWI/SNF-related protein SMARCA3 is a histone H3K23 ubiquitin ligase that regulates H3K9me3 in cancerMolecular CellAugust 7, 2025Ifé Akano, Jakob M. Hebert, Rochelle L. Tiedemann, Qingzeng Gao, Yang Xiao, Nicholas A. Prescott, Yanqing Liu, Kay See Tan, Ryan M. Bastle, Aarthi Ramakrishnan, et al.polyclonal),Abcam,ab17984 Anti-FABP6 (rabbit polyclonal),Abcam,ab96122 Anti-UHRFI (rabbit monoclonal),Cell Signaling Technology,12387 Anti-SUV39H1 (rabbit monoclonal),Abcam,ab309471 Anti-Actin (rabbit polyclonal),Abcam,ab1801 Anti-K63

(5) UHRF1 phase separation mediates stable inheritance of DNA methylation and promotes the proliferation of prostate cancer cellsCell Commun SignalJune 20, 2025Zhean Li, Yihan Wang, Ziqi Yu, Yujia Luo, Yixiang Zhao, Erfei Xue, Junfeng Zhan, Huimin Lu, Fei Sunto incubate it: DNMT1 (Catalog #M30106M, Abmart, Shanghai, China) at 1:500 dilution, UHRF1 (Catalog #12387s, Cell Signaling Technology, Danvers, USA) at 1:1000 dilution, DNMT3A (Catalog #20954-1-AP, Proteintech,

(6) NKX2-5/LHX1 and UHRF1 Establishing a Positive Feedback Regulatory Circuitry Drives Esophageal Squamous Cell Carcinoma through Epigenetic DysregulationAdv Sci (Weinh)April 30, 2025Xukun Li, Dandan Fan, Yong Li, Jian Yuan, Wanyuan Sun, Qinghao Zhu, Ling Qi, Xueling Wu, Jiahui Cai, Tongyang Gong, et al.indicated antibodies (1:1000 dilution; LHX1, ab229474, Abcam; NKX2‐5, PA5‐49431, Invitrogen; UHRF1, 12387S, CST; 1:5000 dilution; β‐actin, A5316, Sigma) at 4 °C overnight, washed with TBST four times at room

(7) Potentiating anti-tumor immunity by re-engaging immune synapse moleculesCell Reports MedicineMarch 18, 2025Xindi Zhou, Tian Xu, Changhe Li, Yufeng He, Yuanzhi Hu, Hao Gong, Jiahui Li, Haitao Jiang, Liang Wen, Yangxin Fu, et al.,Cell Signaling Technology,"Cat# 4412, RRID: AB_1904025" UHRF1 (D6G8E) Rabbit mAb,Cell Signaling Technology,"Cat# 12387, RRID: AB_2715501" Lamin B1 (D9V6H) Rabbit mAb,Cell Signaling Technology,"Cat# 13435, RRID: AB_2737428" Goat

(8) USP7 V517F mutation as a mechanism of inhibitor resistanceNat CommunMarch 14, 2025Yu-Ling Miao, Fengying Fan, Yong-Jun Cheng, Li Jia, Shan-Shan Song, Xia-Juan Huan, Xu-Bin Bao, Jian Ding, Xuekui Yu, Jin-Xue HeCell Signaling Technology (Danvers, MA, USA) against the following: p21 (#2947); Rad18 (#9040); DNMT1 (#5032); UHRF1 (#12387); caspase-3 (#9662); cleaved caspase-3 (#9661); caspase-7 (#12827); cleaved caspase-7 (#8438); PARP1

(9) Structure–Activity Relationship Studies of DNA Methyltransferase 1 Monovalent DegradersJournal of Medicinal ChemistryFebruary 13, 2025Chao Qian, Youngeun Lee, Yulin Han, Yue Zhong, Jujun Zhou, Joel Hrit, Ling Xie, Qin Chen, H. Ümit Kaniskan, Xian Chen, et al.Smurf2 (Cell Signaling Technology, 12024), WWP1 (Abcam, ab43791), Uhrf1 (Cell Signaling Technology, 12387), and β-actin (Cell Signaling, 3700). Blots were imaged using secondary antibodies on LI-COR Odyssey CLx

(10) DNA hypomethylation promotes UHRF1- and SUV39H1/H2-dependent crosstalk between H3K18ub and H3K9me3 to reinforce heterochromatin statesMolecular CellJanuary 16, 2025Yanqing Liu (刘延晴), Joel A. Hrit, Alison A. Chomiak, Stephanie Stransky, Jordan R. Hoffman, Rochelle L. Tiedemann, Ashley K. Wiseman, Leena S. Kariapper, Bradley M. Dickson, Evan J. Worden, et al.,Cell Signaling Technology,Cat#37771; RRID:AB_3076679 UHRF1 (Western blot),Cell Signaling Technology,Cat# 12387; RRID:AB_2715501 UHRF1 (ChIP),Bioworld Technology,Cat# BS7227; RRID:AB_2904595 DNMT1,Abcam,Cat# ab188453;

(11) UHRF1-mediated ubiquitination of nonhomologous end joining factor XLF promotes DNA repair in human tumor cellsJournal of Biological ChemistryNovember 1, 2024Zhiwen Deng, Caiyun Long, Shuzhen Han, Zhishen Xu, Teng Hou, Weili Li, Xingwu Wang, Xiangyu Liuwith 5% CO2. Antibodies and reagents The antibodies used in this study included the following: UHRF1(12387S, CST); XLF(A300-730A, BETHYL); RNF168(21393-1-AP, Proteintech); H3(ab1791, Abcam); GFP(M048-3, MBL);

(12) Latent Epstein-Barr virus infection collaborates with Myc over-expression in normal human B cells to induce Burkitt-like Lymphomas in micePLoS pathogensApril 1, 2024Bristol JA, Nelson SE, Ohashi M, Casco A, Hayes M, Ranheim EA, Pawelski AS, Singh DR, Hodson DJ, Johannsen EC, et al.#4865), anti-TCL1 (Cell Signaling #4042), anti-TDT (Invitrogen #14-9739-82), anti-UHRF1 (Cell Signaling #12387), anti-Tubulin (Sigma #T5168), and anti-Actin (Sigma #A5441). The secondary antibodies used were horseradish

(13) GSK-3484862 targets DNMT1 for degradation in cellsNAR CancerMay 17, 2023Qin Chen, Bigang Liu, Yang Zeng, Jee Won Hwang, Nan Dai, Ivan R Corrêa, Marcos R Estecio, Xing Zhang, Margarida A Santos, Taiping Chen, et al.#67259), H3 (CST, #14269), GAPDH (CST, #2118), Oct4 (CST, #4286), PCNA (CST, #13110), Uhrf1 (CST, #12387), Actin (Sigma-Aldrich, A2228), Myc tag (Sigma-Aldrich, M4439), Flag tag (Sigma-Aldrich, F3165) and

(14) Gene repression through epigenetic modulation by PPARA enhances hepatocellular proliferationiScienceMay 20, 2022Aibara D, Takahashi S, Yagai T, Kim D, Brocker CN, Levi M, Matsusue K, Gonzalez FJ.break the nuclear membrane on ice. Anti-PPARA IgG (Abcam; ab24509), anti-UHRF1 IgG (Cell Signaling; #12387), anti-DNMT1 IgG (Abcam; ab13537), anti-HDAC1 IgG (Abcam; ab7028), anti-H3K9me3 (Active Motif; 61013)

(15) ASCL1 activates neuronal stem cell-like lineage programming through remodeling of the chromatin landscape in prostate cancerNature communicationsApril 27, 2022Nouruzi S, Ganguli D, Tabrizian N, Kobelev M, Sivak O, Namekawa T, Thaper D, Baca SC, Freedman ML, Aguda A, et al.#MA1-014; 1:500), SUZ12 (Cell Signaling cat. #3737S; clone D39F6; 1:1000), UHRF1 (Cell signaling, cat. #12387S: 1:1000). β-actin (Sigma #A2228; clone AC-74; 1:25,000) was used as loading control. IRDye 800CW donkey

(16) IKZF1 selectively enhances homologous recombination repair by interacting with CtIP and USP7 in multiple myelomaInternational journal of biological sciencesJanuary 1, 2022Liu M, Zhang Y, Wu Y, Jin J, Cao Y, Fang Z, Geng L, Yang L, Yu M, Bu Z, et al.(12586, Cell Signaling Technology); GFP (50430-2-AP, Proteintech); FLAG (30503ES20, Yeasen); UHRF1 (12387, Cell Signaling Technology); P5091 (882257-11-6, ChemShuttle); His (66005-1-Ig, Proteintech); Myc (2276,

(17) The histone and non-histone methyllysine reader activities of the UHRF1 tandem Tudor domain are dispensable for the propagation of aberrant DNA methylation patterning in cancer cellsEpigenetics & chromatinOctober 23, 2020Vaughan RM, Kupai A, Foley CA, Sagum CA, Tibben BM, Eden HE, Tiedemann RL, Berryhill CA, Patel V, Shaw KM, et al.quantified by Bradford Assay (BioRad) and 300 µg was added to either 4 µL of anti-UHRF1 antibody (CST 12387, 1 mg/mL) or 4 µL of CSK buffer (bead only) and brought to a final volume of 200 µL. Lysates and antibody

(18) The finger loop of the SRA domain in the E3 ligase UHRF1 is a regulator of ubiquitin targeting and is required for the maintenance of DNA methylationThe Journal of biological chemistryOctober 25, 2019Vaughan RM, Rothbart SB, Dickson BM.PBS with 0.1% Tween 20 (PBST)), incubated with primary antibodies (UHRF1, Cell Signaling Technology, 12387S, 1:1000; H3, EpiCyhper, 13-0001, 1:50,000) overnight at 4 °C in blocking buffer, washed three times

(19) Characterization of DNA hydroxymethylation in the hypothalamus of elderly mice with post‑operative cognitive dysfunctionExperimental and Therapeutic MedicineSeptember 26, 2019Jiang Zhong, Wei Xu(1:2,000; cat. no. ab191698; Abcam), TET2 (1:2,000; cat. no. ab124297; Abcam), Uhrf1 (1:2,000; cat no. 12387; Cell Signaling Technology, Inc.), Uhrf2 (1:2,000; cat. no. ab28673; Abcam) and β-actin (1:5,000; cat.

(20) Maintenance and pharmacologic targeting of ROR1 protein levels via UHRF1 in t(1;19) pre-B-ALLOncogeneSeptember 1, 2018Chow M, Gao L, MacManiman JD, Bicocca VT, Chang BH, Alumkal JJ, Tyner JW.Manuscript Reagents Commercially available antibodies used in this study are: ROR1, UHRF1 (#4102, #12387, Cell Signaling, Danvers MA), ROR1 (#AF2000, R&D Systems, Minneapolis MN), UHRF1 (#612264, BD Biosciences,

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UHRF1 (D6G8E) Rabbit mAb

UHRF1 (D6G8E) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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UHRF1 (D6G8E) Rabbit mAb from Cell Signaling Technology

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