Anti-RAG1 antibodies are used in the immunodetection of the protein recombination activating 1. In humans, the canonical protein has a reported length of 1043 amino acid residues and a mass of 119.1 kDa. Its subcellular localization is in the nucleus. Up to 2 different isoforms have been reported for this protein. A member of the RAG1 protein family, RAG1 is reported to be a catalytic component of the RAG complex, a multiprotein complex that mediates the DNA cleavage phase during V(D)J recombination. Post-translational modifications have been described, including ubiquitination. The RAG1 marker can be used to identify Pro B Progenitor Cells.* Synonyms for this target antigen include V(D)J recombination-activating protein 1, RING finger protein 74, recombination activating gene 1, recombination activating protein 1, and RNF74. RAG1 gene orthologs have been reported in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4