Anti-NECAB3 antibodies are used in the immunodetection of the protein N-terminal EF-hand calcium binding protein 3. In humans, the canonical protein has a reported length of 396 amino acid residues and a mass of 44.4 kDa. Its subcellular localization is in the golgi. Alternative splicing is reported to yield 3 different isoforms for this protein. It is reported to be highly expressed in heart and skeletal muscle, moderately in the brain and pancreas. NECAB3 is reported to inhibit the interaction of APBA2 with amyloid-beta precursor protein (APP), and hence allows formation of amyloid-beta. Post-translational modifications have been described, including phosphorylation. Synonyms for this target antigen include Nek2-interacting protein 1, X11L-binding protein 51, amyloid beta (A4) precursor protein-binding, family A, member 2 binding protein, and EF-hand calcium binding protein 3.