Anti-MS4A1 antibodies are used in the immunodetection of the protein membrane spanning 4-domains A1. In humans, the canonical protein has a reported length of 297 amino acid residues and a mass of 33.1 kDa. Its subcellular localization is in the cell membrane. Up to 2 different isoforms have been reported for this protein. It is noted to be expressed on B-cells. A member of the MS4A protein family, MS4A1 is known to be involved with B cell differentiation and receptor-mediated signaling pathways. Post-translational modifications have been described, including phosphorylation.
The MS4A1 marker can be used to identify Immature B Cells, Memory B Cells, Naive B Cells, Large Intestine Lamina Propria Lymphocytes, and Plasma Cells.* Synonyms for this target antigen include Bp35, CD20, CVID5, FMC7, LEU-16, S7, B-lymphocyte antigen CD20, and B1. MS4A1 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 1700 citations in the literature describe the use of MS4A1 antibodies in research. These antibodies are most commonly used in Flow Cytometry experiments, among other applications.
*HuBMAP Human Reference Atlas v1.4