Anti-LY86 antibodies are used in the immunodetection of the protein lymphocyte antigen 86. In humans, the canonical protein has a reported length of 162 amino acid residues and a mass of 17.9 kDa. It has been described to be a secreted protein. It is reported to be highly expressed in B-cells, monocytes and tonsil. LY86 is believed to cooperate with CD180 and TLR4 to mediate the innate immune response to bacterial lipopolysaccharide (LPS) and cytokine production. Post-translational modifications have been described, including glycosylation.
The LY86 marker can be used to identify Unswitched Memory B Cells and Class Switched Memory B Cells.* Synonyms for this target antigen include MD1, MMD-1, dJ80N2.1, MD-1, RP105-associated, protein MD-1, and MD-1. LY86 gene orthologs have been reported in the mouse, rat, bovine, zebrafish, chimpanzee and chicken species. A number of Ly86 antibodies have been mentioned in research publications and have associated citations. Western Blot is a widely used application for these antibodies. ELISA and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4