Anti-IL5RA antibodies are used in the immunodetection of the protein interleukin 5 receptor subunit alpha. In humans, the canonical protein has a reported length of 420 amino acid residues and a mass of 47.7 kDa. Its subcellular localization is in the membrane. Up to 5 different isoforms have been reported for this protein. It is noted to be expressed on eosinophils and basophils. A member of the Type I cytokine receptor protein family, IL5RA is a reported cell surface receptor that plays an important role in the survival, differentiation, and chemotaxis of eosinophils. Post-translational modifications have been described, including glycosylation. The IL5RA marker can be used to identify Eosinophils, Basophils, and Mast Cells.* Synonyms for this target antigen include CDw125, HSIL5R3, IL5R, CD125 antigen, IL-5 receptor subunit alpha, and CD125. IL5RA gene orthologs have been reported in the mouse, rat, bovine, frog, chimpanzee and chicken species.
*HuBMAP Human Reference Atlas v1.4