Anti-BIRC3 antibodies are used in the immunodetection of the protein baculoviral IAP repeat containing 3. In humans, the canonical protein has a reported length of 604 amino acid residues and a mass of 68.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. It is reported to be highly expressed in fetal lung, and kidney. A member of the IAP protein family, BIRC3 is reported to be a multi-functional protein, which regulates not only caspases and apoptosis, but also modulates inflammatory signaling and immunity, mitogenic kinase signaling and cell proliferation, as well as cell invasion and metastasis.
The BIRC3 marker can be used to identify Naive B Cells.* Synonyms for this target antigen include API2, CIAP2, HAIP1, HIAP1, IAP-1, MALT2, MIHC, and AIP1. BIRC3 gene orthologs have been reported in the mouse, rat, bovine and chimpanzee species. Over 230 citations in the literature describe the use of BIRC3 antibodies in research. Western Blot is a widely used application for these antibodies. In addition, Immunohistochemistry is also a common application.
*HuBMAP Human Reference Atlas v1.4