Anti-BID antibodies are used in the immunodetection of the protein BH3 interacting domain death agonist. In humans, the canonical protein has a reported length of 195 amino acid residues and a mass of 22 kDa. Its subcellular localization is in the mitochondria and cytoplasm. Up to 4 different isoforms have been reported for this protein. It is notably expressed in many tissues, such as the bone marrow, urinary bladder, and appendix. BID is known to be involved with the apoptotic pathway. Post-translational modifications have been described, including ubiquitination and protein cleavage.
The BID marker can be used to identify Schwann Cells, Fat Cells, and Melanocytes.* Synonyms for this target antigen include Human BID coding sequence, apoptic death agonist, desmocollin type 4, p22 BID, and FP497. BID gene orthologs have been reported in the mouse, rat, bovine, chimpanzee and chicken species. Over 380 citations in the literature describe the use of Bid antibodies in research. Western Blot is a widely used application for these antibodies. ELISA, Immunofluorescence, and Immunohistochemistry are also common applications.
*HuBMAP Human Reference Atlas v1.4