Anti-Eph receptor A2 antibodies are used in the immunodetection of the protein encoded by the EPHA2 gene. In humans, the canonical protein has a reported length of 976 amino acid residues and a mass of 108.3 kDa. Its subcellular localization is in the cell membrane. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in the brain and glioma tissue and glioma cell lines. A member of the Tyr protein kinase protein family, it is a known receptor tyrosine kinase which binds promiscuously membrane-bound ephrin-A family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. Post-translational modifications have been described, including glycosylation, ubiquitination and phosphorylation. Other names for this target antigen include CTPA, CTPP1, CTRCT6, ECK, ephrin type-A receptor 2, and ARCC2.