Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb 12677S from Cell Signaling Technology

Product Specs
ItemPhospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb
CompanyCell Signaling Technology
Price $401.00 Inquire
Catalog Number12677S
Quantity100 µl
ApplicationsW, IP
ReactivityH
TargetEphA2 (Tyr588) phosphate
ModificationsEphA2 (Tyr588) phosphate
HostRabbit
NCBI Full Gene NameEPH receptor A2
NCBI Gene AliasesARCC2, CTPA, CTPP1, CTRCT6, ECK
ClonalityMonoclonal
Research AreaRTK
CloneD7X2L
Molecular Weight125

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Cell Signaling Technology

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Danvers, Massachusetts 01923

United States

Phone: 877-616-CELL
Phone: 978-867-2388
Fax: 866-432-6112
Fax: 978-867-2488

Company Profile

Website: http://www.cellsignal.com/

Website: Technical Support

(1) EPHA2/CD44-directed trafficking enhances endosomal leakiness and antisense therapy deliveryJ Cell BiolSeptember 7, 2026Sergi Marco, Peter J. Walsh, Alexey S. Revenko, Tobias Schmidt, Peter A. Thomason, Lynn McGarry, A. Robert MacLeod, Sonam Ansel, Dina Tataran, Martin Bushell, et al.phospho Ser897 rabbit WB 1:1,000 IF 1:200",CST,#6347 "EPHA2 phospho Tyr588 rabbit WB 1:1,000",CST,#12677 "ASO rabbit IF 1:1,000",Ionis Pharma,Ionis 13545 "MEK1/2 total rabbit WB 1:1,000",CST,#9126 "MEK1/2

(2) EGFR endocytosis down-regulates binding to EphA2 at the plasma membraneJournal of Biological ChemistryJune 27, 2026Jennifer A. Rybak, Francisco N. Barreramin at 37 °C. Antibodies Total EGFR (4267), EGFR pY1068 (3777), Total EphA2 (97535), EphA2 pY588 (12677), and EphA2 pS897 (6347) antibodies were obtained from Cell Signaling Technology (CST) and diluted 1:1000

(3) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscoveryMarch 2, 2026Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.Signaling Technology, cat. #6997, RRID: AB_10827743), p-EPHA2Tyr588 (Cell Signaling Technology, cat. #12677, RRID: AB_2797989), ERK1/2 (Cell Signaling Technology, cat. #9102, RRID: AB_330744), p-ERK1/2Tyr202/204

(4) Frequent EPHA2 receptor mutations in cholangiocarcinoma disrupt receptor forward signaling supporting a tumor suppressor roleBiochimica et Biophysica Acta (BBA) - Molecular Cell ResearchJanuary 1, 2026Evodie Koutouan, Alejandro Lillo, Ayano Kabashima, Jack W. Sample, Danielle Carlson, Rondell Graham, Rory L. Smoot, Elena B. Pasqualefrom Cell Signaling Technology to label EPHA2 (6997; 1:3,000 dilution), EPHA2 phosphorylated on Y588 (12677; 1:1,000 dilution), EPHA2 phosphorylated on Y772 (8244, at 1:2,000 dilution), EPHA2 phosphorylated on

(5) PTEN Loss Promotes PI3Kβ Phosphorylation and EPHA2/SRC/p-PI3KβY962 Complex Assembly to Drive TumorigenesisCancer DiscovNovember 17, 2025Shuang Tang, Qian Zhou, Johann S. Bergholz, Tao Jiang, Weihua Wang, Renlei Ji, Wendi Huang, Jiachen Wu, Yutong Li, Xiaochun Wan, et al.Signaling Technology, cat. #6997, RRID: AB_10827743), p-EPHA2Tyr588 (Cell Signaling Technology, cat. #12677, RRID: AB_2797989), ERK1/2 (Cell Signaling Technology, cat. #9102, RRID: AB_330744), p-ERK1/2Tyr202/204

(6) EphA2 and Ephrin-A1 Utilize the Same Interface for Both in cis and in trans Interactions That Differentially Regulate Cell Signaling and FunctionbioRxiv : the preprint server for biologyAugust 2, 2025Kim S, Toth P, Wang W, Seiradake E, Shi X, Wang B.#10882-H08H). Antibodies: Rabbit monoclonal Anti-phospho-EphA2 (Tyr588, Cell Signaling Technology, #12677S); Rabbit monoclonal Anti-phospho-EphA2 (Cell Signaling Technology, #6997S); Rabbit polyclonal Anti-ephrin-A1

(7) Targeting Glioblastoma Stem Cells via EphA2: Structural Insights into the RNA Aptamer A40s for Precision TherapyJournal of Chemical Information and ModelingJune 9, 2025Isidora Diakogiannaki, Vincenzo Maria D’Amore, Alessandra Affinito, Greta Donati, Elpidio Cinquegrana, Cristina Quintavalle, Martina Mascolo, Jule Walter, Heike Betat, Mario Mörl, et al.Biotechnologies (Texas, USA) and phosphor-Akt Ser473 (9271), Akt pan (4685), phosphor-EphA2 Tyr588 (12677), and Phospho RSK2Ser227 (D53A11) from Cell Signaling Technology (Milan, Italy). Bands were quantified

(8) Synthetic antibodies targeting EphA2 induce diverse signaling-competent clusters with differential activationProtein SciMay 24, 2025Jarrett J. Adams, Heather A. Bruce, Suryasree Subramania, Lynda Ploder, Julia Garcia, Isabelle Pot, Levi L. Blazer, Alexander U. Singer, Sachdev S. Sidhubefore probing for target proteins. Primary Abs used were rabbit phospho‐EphA2, Tyr588 (Cell Signaling 12677, 1:1000), rabbit GAPDH (Cell Signaling 2118, 1:20,000), rabbit phospho‐EphA2, Tyr772 (Cell Signaling,

(9) Cholesterol inhibits assembly and oncogenic activation of the EphA2 receptorCommun BiolMarch 11, 2025Ryan J. Schuck, Alyssa E. Ward, Amita R. Sahoo, Jennifer A. Rybak, Robert J. Pyron, Thomas N. Trybala, Timothy B. Simmons, Joshua A. Baccile, Ioannis Sgouralis, Matthias Buck, et al.anti-phospho-EphA2 (Ser897) (D9A1) (CST 6347; 1:1000), rabbit anti-phospho-EphA2 (Tyr588) (D7X2L) (CST 12677;1:1000), rabbit anti-PKA C-α (CST 5842; 1:1000), rabbit anti-phospho-PKA C (Thr197) (D45D3) (CST 5661;

(10) Phosphatidylinositol 4,5-bisphosphate drives the formation of EGFR and EphA2 complexesScience AdvancesDecember 6, 2024Pradeep Kumar Singh, Jennifer A. Rybak, Ryan J. Schuck, Amita R. Sahoo, Matthias Buck, Francisco N. Barrera, Adam W. SmithTBS,1:1000,Rabbit pEGFR(Y1068),"3777S, CST",3% BSA in TBS,1:1000,Rabbit Total EphA2,"97535S, CST",5% Milk,1:1000,Rabbit pEphA2(Y588),"12677, CST",3% BSA,1:1000,Rabbit pEphA2(S897),"6347S, CST",3% BSA,1:1000,Rabbit Actin,"3700S, CST",5% milk,1:5000,Mouse Anti-mouse,"925-68020,

(11) Canonical ligand-dependent and non-canonical ligand-independent EphA2 signaling in the eye lens of wild-type, knockout, and aging miceAging (Albany NY)October 25, 2024Jenna L. Horner, Michael P. Vu, Jackson T. Clark, Isaiah J. Innis, Catherine Chenganti-EphA2-pS897 antibody (6347, Cell Signaling Technology) or 1:50 of a rabbit-EphA2-pY588 antibody (12677, Cell Signaling Technology). While both antibodies against the phosphorylated forms of EphA2 were made

(12) Cholesterol inhibits assembly and activation of the EphA2 receptorbioRxivJune 16, 2024Ryan J Schuck, Alyssa E Ward, Amita R Sahoo, Jennifer A Rybak, Robert J Pyron, Thomas N Trybala, Timothy B Simmons, Joshua A Baccile, Ioannis Sgouralis, Matthias Buck, et al.anti-phospho-EphA2 (Ser897) (D9A1) (CST 6347; 1:1000), rabbit anti-phospho-EphA2 (Tyr588) (D7X2L) (CST 12677;1:1000), rabbit anti-PKA C-α (CST 5842; 1:1000), rabbit anti-phospho-PKA C (Thr197) (D45D3) (CST 5661;

(13) Lipidation and PEGylation strategies to prolong the in vivo half-life of a nanomolar EphA4 receptor antagonistEuropean Journal of Medicinal ChemistryDecember 15, 2023Maricel Gomez-Soler, Erika J. Olson, Elena Rubio Rubio de la Torre, Chunxia Zhao, Ilaria Lamberto, Dillon T. Flood, Waleed Danho, Bernhard C. Lechtenberg, Stefan J. Riedl, Philip E. Dawson, et al.with TBST, incubated for 1.5 hour at room temperature with 100 μl/well anti-EphA2 pY588 antibody (#12677S, Cell Signaling Technology), diluted 1:4,000 in TBST. Wells were then washed 5 times with TBST, incubated

(14) Ligands with different dimeric configurations potently activate the EphA2 receptor and reveal its potential for biased signalingiScienceMarch 18, 2022Gomez-Soler M, Gehring MP, Lechtenberg BC, Zapata-Mercado E, Ruelos A, Matsumoto MW, Hristova K, Pasquale EB.incubated in the cold overnight with antibodies from Cell Signaling Technology recognizing EphA2 pY588 (#12677, at 1:2,000 dilution), EphA2 pY772 (#8244, at 1:1,000), EphA2 (#6997 at 1:1,000 dilution), AKT pS473

(15) Exosomal EPHA2 derived from highly metastatic breast cancer cells promotes angiogenesis by activating the AMPK signaling pathway through Ephrin A1-EPHA2 forward signalingTheranosticsJanuary 1, 2022Han B, Zhang H, Tian R, Liu H, Wang Z, Wang Z, Tian J, Cui Y, Ren S, Zuo X, et al.(4695, CST), p-ERK (4370, CST), Akt (9272, CST), p-Akt (2965, CST), EPHA2 (6997, CST), p-EPHA2(Tyr588) (12677,CST), Ephrin A1 (124911, Abcam) and β-actin (A1978, Sigma-Aldrich, MO, USA). After washing three times

(16) EphA2 signaling within integrin adhesions regulates fibrillar adhesion elongation and fibronectin depositionMatrix biology : journal of the International Society for Matrix BiologySeptember 1, 2021Finney AC, Scott ML, Reeves KA, Wang D, Alfaidi M, Schwartz JC, Chitmon CM, Acosta CH, Murphy JM, Alexander JS, et al.(1:1000, CST #4702), rabbit anti-EphA2 (1:1000, CST #6997), rabbit anti-phospho-EphA2 Y588 (1:1000, CST #12677), rabbit anti-phospho-EphA2 Y772 (1:1000, CST #8244), rabbit anti-phospho-EphA2 S897 (1:1000, CST #6347),

(17) Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobilityeLifeAugust 20, 2021Zhongwen Chen, Dongmyung Oh, Kabir Hassan Biswas, Ronen Zaidel-Bar, Jay T Grovesinclude rabbit anti-EphA2 (CST, 6997), rabbit anti-pErk (CST, 9101), and rabbit anti-pY588-EphA2 (CST, 12677). The secondary antibody is goat anti-rabbit antibody conjugated with Alexa 488 fluorophores (Thermo

(18) Probing the effect of clustering on EphA2 receptor signaling efficiency by subcellular control of ligand-receptor mobilityElifeAugust 20, 2021Zhongwen Chen, Dongmyung Oh, Kabir Hassan Biswas, Ronen Zaidel-Bar, Jay T Grovesinclude rabbit anti-EphA2 (CST, 6997), rabbit anti-pErk (CST, 9101), and rabbit anti-pY588-EphA2 (CST, 12677). The secondary antibody is goat anti-rabbit antibody conjugated with Alexa 488 fluorophores (Thermo

(19) Aggressive and recurrent ovarian cancers upregulate ephrinA5, a non-canonical effector of EphA2 signaling dualityScientific reportsApril 23, 2021Jukonen J, Moyano-Galceran L, Höpfner K, Pietilä EA, Lehtinen L, Huhtinen K, Gucciardo E, Hynninen J, Hietanen S, Grénman S, et al.1:1000, IF: 1:100), anti-EphA2-pS897 (#6347, Cell Signaling Technologies, IB: 1:1000), anti-EphA2-pY588 (#12677, Cell Signaling Technologies, IB: 1:1000), anti-ephrinA1 (sc-911, Santa Cruz, IB: 1:1000), anti-ephrinA5

(20) Targeting EphA2 suppresses hepatocellular carcinoma initiation and progression by dual inhibition of JAK1/STAT3 and AKT signalingCell reportsFebruary 23, 2021Wang H, Hou W, Perera A, Bettler C, Beach JR, Ding X, Li J, Denning MF, Dhanarajan A, Cotler SJ, et al.RESOURCE,SOURCE,IDENTIFIER Antibodies,Antibodies,Antibodies EphA2 (C-3),Santa Cruz,sc-398832 EphA2 (phospho Y588) (D7X2L),Cell signaling,12677S; RRID:AB_2797989 EphA2 (phospho S897) (D9A1),Cell signaling,6347S; RRID:AB_11220420 Goat anti-Mouse

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Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb

Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb from Cell Signaling Technology

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Cell Signaling Technology

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Phospho-EphA2 (Tyr588) (D7X2L) Rabbit mAb from Cell Signaling Technology

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