Anti-argonaute RISC component 4 antibodies are used for the immunodetection of the protein encoded by the AGO4 gene. In humans, the canonical protein has a reported length of 861 amino acid residues and a mass of 97.1 kDa. Its subcellular localization is in the cytoplasm. A member of the Argonaute protein family, it is known to be required for RNA-mediated gene silencing (RNAi). Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include argonaute 4, RISC catalytic component, argonaute RISC catalytic component 4, eukaryotic translation initiation factor 2C, 4, and protein argonaute-4. Gene orthologs have been identified in the mouse, rat, bovine and chimpanzee species.