Anti-CWC27 spliceosome associated cyclophilin antibodies are used for the immunodetection of the protein encoded by the CWC27 gene. In humans, the canonical protein has a reported length of 472 amino acid residues and a mass of 53.8 kDa. Its subcellular localization is in the nucleus. Alternative splicing is reported to yield 2 different isoforms for this protein. A member of the Cyclophilin-type PPIase protein family, it is known to be involved with RNA splicing and protein folding. Post-translational modifications have been described, including glycosylation. The gene encoding this protein is implicated in Retinitis pigmentosa with or without skeletal anomalies. Other names for this target antigen include RPSKA, SDCCAG-10, SDCCAG10, spliceosome-associated protein CWC27 homolog, CWC27 spliceosome associated protein homolog, and NY-CO-10. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.