Anti-PVR cell adhesion molecule antibodies are used for the immunodetection of the protein encoded by the PVR gene. In humans, the canonical protein has a reported length of 417 amino acid residues and a mass of 45.3 kDa. Its subcellular localization is in the cell membrane and is secreted. Alternative splicing is reported to yield 4 different isoforms for this protein. A member of the Nectin protein family, it is known to mediate NK cell adhesion and triggers NK cell effector functions. Post-translational modifications have been described, including N-glycosylation and phosphorylation. Other names for this target antigen include HVED, NECL5, Necl-5, PVS, TAGE4, poliovirus receptor, nectin-like protein 5, and CD155. Gene orthologs have been identified in the bovine and chimpanzee species.