Anti-argonaute RISC component 1 antibodies are used for the immunodetection of the protein encoded by the AGO1 gene. In humans, the canonical protein has a reported length of 857 amino acid residues and a mass of 97.2 kDa. Its subcellular localization is in the cytoplasm. A member of the Argonaute protein family, it is known to be required for RNA-mediated gene silencing (RNAi). Post-translational modifications have been described, including ubiquitination. Other names for this target antigen include EIF2C1, GERP95, NEDLBAS, Q99, hAgo1, protein argonaute-1, Golgi Endoplasmic Reticulum protein 95 kDa, and EIF2C. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.