Anti-RUNX family transcription factor 3 antibodies are used for the immunodetection of the protein encoded by the RUNX3 gene. In humans, the canonical protein has a reported length of 415 amino acid residues and a mass of 44.4 kDa. Its subcellular localization is in the nucleus and cytoplasm. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in gastric cancer tissues. It is noted to be involved in the regulation of transcription and the regulation of cell differentiation. Post-translational modifications have been described, including phosphorylation. Other names for this target antigen include CBFA3, PEBP2aC, runt-related transcription factor 3, CBF-alpha-3, PEA2 alpha C, and AML2. Gene orthologs have been identified in the mouse, rat, bovine, frog, zebrafish, chimpanzee and chicken species.