Anti-cellular communication network factor 2 antibodies are used for the immunodetection of the protein encoded by the CCN2 gene. In humans, the canonical protein has a reported length of 349 amino acid residues and a mass of 38.1 kDa. Its subcellular localization is in the extracellular matrix and is secreted. Alternative splicing is reported to yield 2 different isoforms for this protein. It is reported to be expressed in bone marrow and thymic cells. A member of the CCN protein family, it is known to be involved with pathways of aging and angiogenesis. Post-translational modifications have been described, including glycosylation. Other names for this target antigen include HCS24, IGFBP8, CCN family member 2, IBP-8, IGF-binding protein 8, IGFBP-8, connective tissue growth factor, and CTGF. Gene orthologs have been identified in the mouse, rat, bovine, frog, chimpanzee and chicken species.